AI Article Synopsis
- A new method for selectively iodinating 8-methylquinolines using an efficient Pd-catalyzed process has been developed for the first time.
- *The technique allows for easy production of various C8-substituted quinolines, showcasing the versatility of organic iodides.
- *By adjusting the reaction conditions, the same method can also achieve effective acetoxylation of 8-methylquinolines, with both strategies exhibiting mild conditions and good compatibility with different functional groups.
Article Abstract
An efficient Pd-catalyzed C(sp)-H selective iodination of 8-methylquinolines is reported herein for the first time. Because of the versatility of organic iodides, the method offers a facile access to various C8-substituted quinolines. By slightly switching the reaction conditions, an efficient C(sp)-H acetoxylation of 8-methylquinolines has also been enabled. Both approaches feature mild reaction conditions, good tolerance of functional groups, and a broad substrate scope.
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| http://dx.doi.org/10.1021/acs.joc.2c00076 | DOI Listing |
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