AI Article Synopsis
- - The study examined over 18,000 cases of Clostridioides difficile infection (CDI) in Canadian hospitals from 2015 to 2019, finding that healthcare-associated (HA) infections accounted for 74.4% while community-associated (CA) infections made up 25.6%.
- - During the study period, HA CDI rates dropped by 23.8% and CA rates by 18.8%, with HA CDI linked to higher 30-day mortality rates compared to CA CDI.
- - The most prevalent ribotypes were RT027, RT106, RT014, and RT020, with RT027 showing a stronger association with CDI-related deaths; the findings emphasize the need for ongoing infection prevention
Article Abstract
We investigated epidemiologic and molecular characteristics of healthcare-associated (HA) and community-associated (CA) Clostridioides difficile infection (CDI) among adult patients in Canadian Nosocomial Infection Surveillance Program hospitals during 2015-2019. The study encompassed 18,455 CDI cases, 13,735 (74.4%) HA and 4,720 (25.6%) CA. During 2015-2019, HA CDI rates decreased by 23.8%, whereas CA decreased by 18.8%. HA CDI was significantly associated with increased 30-day all-cause mortality as compared with CA CDI (p<0.01). Of 2,506 isolates analyzed, the most common ribotypes (RTs) were RT027, RT106, RT014, and RT020. RT027 was more often associated with CDI-attributable death than was non-RT027, regardless of acquisition type. Overall resistance C. difficile rates were similar for all drugs tested except moxifloxacin. Adult HA and CA CDI rates have declined, coinciding with changes in prevalence of RT027 and RT106. Infection prevention and control and continued national surveillance are integral to clarifying CDI epidemiology, investigation, and control.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155897 | PMC |
| http://dx.doi.org/10.3201/eid2806.212262 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Australian Group on Antimicrobial Resistance (AGAR) Australian Staphylococcus aureus Surveillance Outcome Program (ASSOP) Bloodstream Infection Annual Report 2023.
Commun Dis Intell (2018)
December 2024
School of Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, Western Australia, Australia.
From 1 January to 31 December 2023, fifty-seven institutions across Australia participated in the Australian Surveillance Outcome Program (ASSOP). The aim of ASSOP 2023 was to determine the proportion of bacteraemia (SAB) isolates in Australia that were antimicrobial resistant, with particular emphasis on methicillin resistance, and to characterise the methicillin-resistant (MRSA) molecular epidemiology. A total of 3,422 SAB episodes were reported, of which 77.
View Article and Find Full Text PDFTrends in SARS-CoV-2-related pediatric hospitalizations reported to the Canadian Nosocomial Infection Surveillance Program, March 2020 to December 2022.
Antimicrob Steward Healthc Epidemiol
October 2024
Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
Article Synopsis
- * 81% of the 5,143 pediatric cases occurred during the Omicron period, with fewer children needing intensive care compared to pre-Omicron times (11% vs. 14%), but no notable difference in mortality rates was found.
- * The findings emphasize that many hospitalized children had pre-existing health conditions and indicate a surge in healthcare-associated COVID-19 cases during Omicron, although overall disease severity appeared to decline.
Multicenter study on infections in Mexico: exploring the landscape.
Infect Control Hosp Epidemiol
October 2024
Hospital Universitario "Dr. José Eleuterio González", Monterrey, Mexico.
Article Synopsis
- - The study examined Clostridioides difficile infection (CDI) trends and outcomes in 16 healthcare facilities in Mexico from 2016 to 2022, focusing on patient demographics and clinical data.
- - Out of 2,356 CDI cases identified, 90% were healthcare-associated, with common comorbidities including hypertension and diabetes; the 30-day mortality rate was 16%.
- - The findings highlight the need for improved surveillance and standardized CDI classification in Mexico, noting stable rates but differences in incidence between public and private hospitals.
Diverse Sources and Latent Reservoirs of Community-Associated Clostridioides difficile Infection.
Clin Infect Dis
August 2024
School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Clostridioides difficile (C. difficile) is a spore-forming, toxin-producing, anaerobic bacterium infecting the human gastrointestinal tract, causing diarrhea and life-threatening colitis. C.
View Article and Find Full Text PDFHealthcare-associated infections and antimicrobial resistance in Canadian acute care hospitals, 2018-2022.
Can Commun Dis Rep
June 2024
Background: Healthcare-associated infections (HAIs) and antimicrobial resistance (AMR) continue to contribute to excess morbidity and mortality among Canadians.
Objective: This report describes epidemiologic and laboratory characteristics and trends of HAIs and AMR from 2018 to 2022 (, 2012-2022) using surveillance and laboratory data submitted by hospitals to the Canadian Nosocomial Infection Surveillance Program (CNISP) and by provincial and territorial laboratories to the National Microbiology Laboratory.
Methods: Data collected from 88 Canadian sentinel acute care hospitals between January 1, 2018, and December 31, 2022, for infections (CDIs), carbapenemase-producing (CPE) infections, methicillin-resistant (MRSA) bloodstream infections (BSIs) and vancomycin-resistant (VRE) BSIs.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!