A series of digermylenes R(EGeL) (L=CH[C(Me)N(Ar)] , Ar=2,6-iPr C H ; E=O, R=1,3-C H (1), 1,4-C H (2), Me C(CH ) (3); E=NH, R=1,4-C H (4), 1,4-C H (5); E=C(O)O, R=1,3-C H (6)) were synthesized by the reactions of L'Ge (L'=HC[C(CH )N(Ar)]C(Me)N(Ar), Ar=2,6-iPr C H ) with selected diphenols, diol, diamines, and o-/m-phthalic acids, respectively. Treatment of digermylene 1,3-C H (OGeL) (1) with sulfur, selenium and CuX (X=Cl, Br, I) led to the formation of 1,3-C H [OGe(S)L] (8), 1,3-C H [OGe(Se)L] (9), and (CuX) [1,3-C H (OGeL) ] (X=Cl (10), Br (11), I (12)), respectively. The obtained products were characterized by melting point, elemental analysis, FT-IR, H and C NMR spectroscopy, and single-crystal X-ray diffraction.
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http://dx.doi.org/10.1002/asia.202200141 | DOI Listing |
Elife
January 2025
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, United States.
Single-nucleus RNA sequencing (snRNA-seq), an alternative to single-cell RNA sequencing (scRNA-seq), encounters technical challenges in obtaining high-quality nuclei and RNA, persistently hindering its applications. Here, we present a robust technique for isolating nuclei across various tissue types, remarkably enhancing snRNA-seq data quality. Employing this approach, we comprehensively characterize the depot-dependent cellular dynamics of various cell types underlying mouse adipose tissue remodeling during obesity.
View Article and Find Full Text PDFJAMA Neurol
January 2025
Department of Radiology, Mayo Clinic, Rochester, Minnesota.
Importance: Although 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a well-established cross-sectional biomarker of brain metabolism in dementia with Lewy bodies (DLB), the longitudinal change in FDG-PET has not been characterized.
Objective: To investigate longitudinal FDG-PET in prodromal DLB and DLB, including a subsample with autopsy data, and report estimated sample sizes for a hypothetical clinical trial in DLB.
Design, Setting, And Participants: Longitudinal case-control study with mean (SD) follow-up of 3.
Heart Fail Rev
January 2025
Department of Cardiology, Cardiology I, University Medical Center Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany.
Heart failure is a prevalent global health issue. Heart failure with preserved ejection fraction (HFpEF), which already represents half of all heart cases worldwide, is projected to further increase, driven by aging populations and rising cardiovascular risk factors. Effective therapies for HFpEF remain limited, particularly due to its pathophysiological heterogeneity and incomplete understanding of underlying pathomechanisms and implications.
View Article and Find Full Text PDFAppl Microbiol Biotechnol
January 2025
Department of Microbiology and Biotechnology, Institute of Plant Science and Microbiology, University of Hamburg, Ohnhorststr.18, 22609, Hamburg, Germany.
The focus on microalgae for applications in several fields, e.g. resources for biofuel, the food industry, cosmetics, nutraceuticals, biotechnology, and healthcare, has gained increasing attention over the last decades.
View Article and Find Full Text PDFPlant Foods Hum Nutr
January 2025
Centro de Desarrollo de Productos Bióticos, Instituto Politécnico Nacional, Col. San Isidro, Km 8.5 Carr. Yautepec-Jojutla, Yautepec, Morelos, C.P. 62731, México.
The relationship between the gut microbiota (GM) and the health of human beings has been a topic of growing interest in the last few years. Legumes are a rich source of indigestible carbohydrates, including resistant starch (RS), which are substrates of the GM. The aim of this study was to evaluate the effect of the indigestible fraction of legumes on the fecal microbiota of normal-weight (NW) and obese (O) donors.
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