Background: Vibrio cholerae O1/O139 were the predominant circulating serogroups exhibiting multi-drug resistance (MDR) during the cholera outbreak which led to cholera treatment failures.
Objective: This meta-analysis aimed to evaluate the weighted pooled resistance (WPR) rates in V. cholerae O1/O139 isolates obtained from environmental samples.
Methods: We systematically searched the articles in PubMed, Scopus, and Embase (until January 2020). Subgroup analyses were then employed by publication year, geographic areas, and the quality of studies. Statistical analyses were conducted using STATA software (ver. 14.0).
Results: A total of 20 studies investigating 648 environmental V. cholerae O1/O139 isolates were analysed. The majority of the studies were originated from Asia (n = 9). In addition, a large number of studies (n = 15 i.e. 71.4%) included in the meta-analysis revealed the resistance to cotrimoxazole and ciprofloxacin. The WPR rates were as follows: cotrimoxazole 59%, erythromycin 28%, tetracycline 14%, doxycycline 5%, and ciprofloxacin 0%. There was increased resistance to nalidixic acid, cotrimoxazole, furazolidone, and tetracycline while a decreased resistance to amoxicillin, ciprofloxacin, erythromycin, chloramphenicol, ampicillin, streptomycin, and ceftriaxone was observed during the years 2000-2020. A significant decrease in the doxycycline and ciprofloxacin-resistance rates in V. cholerae O1/O139 isolates was reported over the years 2011-2020 which represents a decrease in 2001-2010 (p < 0.05).
Conclusions: Fluoroquinolones, gentamicin, ceftriaxone, doxycycline, kanamycin, and cefotaxime showed the highest effectiveness and the lowest resistance rate. However, the main interest is the rise of antimicrobial resistance in V. cholerae strains especially in low-income countries or endemic areas, and therefore, continuous surveillance, careful appropriate AST, and limitation on improper antibiotic usage are crucial.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036709 | PMC |
| http://dx.doi.org/10.1186/s13756-022-01100-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Whole Genome Sequencing of a Non-O1/O139-Group Isolated from a Patient with a Bloodstream Infection.
Infect Drug Resist
December 2024
Department of Biomedical Sciences Laboratory, Wenzhou Medical University Affiliated Dongyang Hospital, Dongyang, Zhejiang, People's Republic of China.
Background: Diarrhea caused by non-O1/O139-group e (NOVC) tends to be mild and can be readily overlooked. In this report, a NOVC strain designated XXM was isolated from the blood of a 68-year-old male undergoing surgical treatment for a bile duct malignancy in October 2023.
Methods: XXM was identified through a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS).
Article Synopsis
- Bacterial infections like V. cholerae are a growing public health issue, particularly in areas with poor sanitation and unsafe drinking water, leading to serious complications like septicemic shock.
- A recent case in Bangladesh involved a 30-year-old man with a history of beta-thalassemia who died from severe complications linked to V. cholerae bacteremia, highlighting the pathogen's deadly potential beyond cholera.
- This case is significant as it provides the first detailed molecular analysis of fatal V. cholerae bacteremia in Bangladesh, emphasizing the urgent need for better investigations into bacterial septicemia to avoid future fatalities.
Case report: Detection of non-O1/non-O139 in a patient with hepatic space-occupying lesions using metagenomic next-generation sequencing.
Front Med (Lausanne)
November 2024
Changsha KingMed Diagnostics Group Co., Ltd., Changsha, Hunan, China.
Article Synopsis
- The study focuses on cholera infections, specifically rare cases linked to hepatic space-occupying lesions, and highlights the effectiveness of metagenomic sequencing (mNGS) for accurate pathogen identification.
- A 75-year-old man experienced diarrhea and fever after eating crabs, leading to the discovery of a liver abscess, which was diagnosed as a non-O1/O139 cholera infection through mNGS and PCR.
- The case underscores the potential of mNGS to diagnose challenging infections that other traditional methods may miss, paving the way for better clinical outcomes.
Antimicrobial Resistance of Environmental V. cholerae Non-O1/O139 Isolates: Systematic Review and Meta-analysis.
Infect Disord Drug Targets
October 2024
Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.
Background: The understanding of the antibiotic resistance status of environmental nonO1/nonO139 V. cholerae [NOVC] in relation to other illnesses, which can vary in severity from mild to life-threatening, is limited. However, it is important to note that NOVC-related infections are increasing and serve as a significant illustration of emerging human diseases associated with climate change.
View Article and Find Full Text PDFCase report: Characterization and bioinformatics analysis of non-O1/O139 strain isolated from a choledochoduodenal fistula patient with septicemia.
Front Med (Lausanne)
October 2024
Department of Infectious Diseases, People's Hospital of Xiushan County, Xiushan, China.
The gram-negative bacterium (VC) is divided into multiple serogroups, with groups O1 and O139 responsible for cholera. Conversely, belonging to the non-O1/non-O139 group (NOVC) does not produce cholera-causing toxins. Insufficient understanding of the frequency of NOVC causes fear during the early detection phase.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!