Background: Speech-induced action myoclonus may occur as a component of a generalized myoclonus syndrome. However, it may also present in isolation, or with a paucity of other findings, and be diagnostically challenging.
Objectives: To report a retrospective case series of restricted speech-induced action myoclonus.
Methods: We reviewed cases of speech-induced action myoclonus evaluated at Mayo Clinic Rochester from 1989 to 2020. We eliminated cases where a more generalized myoclonic disorder was also present. Clinical, imaging, and electrophysiologic data were extracted.
Results: Four cases were identified in which speech-induced action myoclonus of craniofacial muscles was the predominant clinical presentation. All described cranial muscle twitching induced by speaking, and two cases also reported speech interruptions. Diagnosis was confirmed by expert speech pathologists in all cases. Diagnostic aids included modulation with different speech tasks and speaking rates, and surface electrophysiology which confirmed craniofacial myoclonus induced by speaking tasks (three cases). Previous misdiagnosis included functional, dystonic, neuromuscular junction pathology, or hemifacial spasm. Two cases had isolated speech-induced myoclonus, and the other two had coexistent upper limb tremor. Potential etiologic factors were identified in three cases - medication (2), epilepsy (1) - while in one patient no cause was identified. One patient partially improved with anti-myoclonic medication and speech therapy.
Conclusions: Speech-induced action myoclonus may occur in isolation and is frequently misdiagnosed. Diagnostic aids include modulation with different speech tasks and speaking rates, and surface electrophysiology.
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Speech-induced suppression and vocal feedback sensitivity in human cortex.
Elife
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Neurology Department, New York University, New York, United States.
Across the animal kingdom, neural responses in the auditory cortex are suppressed during vocalization, and humans are no exception. A common hypothesis is that suppression increases sensitivity to auditory feedback, enabling the detection of vocalization errors. This hypothesis has been previously confirmed in non-human primates, however a direct link between auditory suppression and sensitivity in human speech monitoring remains elusive.
View Article and Find Full Text PDFSpeech-induced action myoclonus.
Parkinsonism Relat Disord
May 2022
Division of Movement Disorders, Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address:
Background: Speech-induced action myoclonus may occur as a component of a generalized myoclonus syndrome. However, it may also present in isolation, or with a paucity of other findings, and be diagnostically challenging.
Objectives: To report a retrospective case series of restricted speech-induced action myoclonus.
Speech-Induced Suppression for Delayed Auditory Feedback in Adults Who Do and Do Not Stutter.
Front Hum Neurosci
April 2020
Department of Cognitive Science, Macquarie University, Sydney, NSW, Australia.
Speech-induced suppression is the normal, relative amplitude reduction of the auditory evoked potential for self-, compared to externally-generated, auditory stimulation. It remains controversial as to whether adults who stutter exhibit expected auditory modulation during speech; some studies have reported a significant difference between stuttering and fluent groups in speech-induced suppression during speech movement planning, while others have not. We compared auditory evoked potentials (N1 component) for auditory feedback arising from one's own voice (Speaking condition) with passive listening to a recording of one's own voice (Listening condition) in 24 normally-fluent speakers and 16 adults who stutter under various delayed auditory feedback (DAF) time conditions (100 ms, 200 ms, 500 ms, and 1,000 ms).
View Article and Find Full Text PDFError-dependent modulation of speech-induced auditory suppression for pitch-shifted voice feedback.
BMC Neurosci
June 2011
Speech Physiology Laboratory, Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL 60208, USA.
Background: The motor-driven predictions about expected sensory feedback (efference copies) have been proposed to play an important role in recognition of sensory consequences of self-produced motor actions. In the auditory system, this effect was suggested to result in suppression of sensory neural responses to self-produced voices that are predicted by the efference copies during vocal production in comparison with passive listening to the playback of the identical self-vocalizations. In the present study, event-related potentials (ERPs) were recorded in response to upward pitch shift stimuli (PSS) with five different magnitudes (0, +50, +100, +200 and +400 cents) at voice onset during active vocal production and passive listening to the playback.
View Article and Find Full Text PDFSomatosensory neurons in human thalamus respond to speech-induced orofacial movements.
Brain Res
April 1990
Division of Speech Pathology, Faculty of Medicine, University of Toronto, Ont., Canada.
As part of stereotactic surgery, microelectrode recordings of somatosensory neurons in thalamus were obtained in 5 patients. Neurons with receptive fields on the lips and tongue were consistently activated when these structures were involved in production of speech sounds. The magnitudes of these responses were similar to those elicited by experimentally applied mechanical stimuli, suggesting that speech-induced somatosensory inputs are not suppressed at the thalamic level.
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