George Lewis Elliot has not been given his proper due as the first dean of dentistry in Canada. Elliot was in the center of a scandal, surrounding his establishment of a private dental school, the Canada College of Dentistry. Faced with a regulatory body whose leaders he perceived to be engaging in the practice "choking off" and "stamping out" their competitors, Elliot undertook to create an independent dental school to provide prospective licentiates with the means to pass the board exams, thereby also improving the profession.
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Infect Immun
December 2024
Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.
The incidence of infections attributed to antimicrobial-resistant (AMR) pathogens has increased exponentially over the recent decades reaching 1.27 million deaths worldwide in 2019. Without intervention, these infections are predicted to cause up to 10 million deaths a year and incur costs of up to 100 trillion US dollars globally by 2050.
View Article and Find Full Text PDFAnti-HIV envelope broadly neutralizing antibodies (bnAbs) are alternatives to conventional antiretrovirals with the potential to prevent and treat infection, reduce latent reservoirs, and/or mediate a functional cure. Clinical trials with "first generation" bnAbs used alone or in combination show promising antiviral effects but also highlight that additional engineering of "enhanced" antibodies will be required for optimal clinical utility, while preserving or enhancing cGMP manufacturing capability. Here we report the engineering of an anti-CD4 binding-site (CD4bs) bnAb, N49P9.
View Article and Find Full Text PDFMath Biosci
October 2024
Department of Mathematics, Virginia Polytechnic Institute and State University, 225 Stanger Street, Blacksburg, 24060, VA, USA; Virginia Tech Center for the Mathematics of Biosystems, Virginia Tech, Blacksburg, VA, USA. Electronic address:
Vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in transient antibody response against the spike protein. The individual immune status at the time of vaccination influences the response. Using mathematical models of antibody decay, we determined the dynamics of serum immunoglobulin G (IgG) and serum immunoglobulin A (IgA) over time.
View Article and Find Full Text PDFJ Infect Dis
July 2024
Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Generation of a stable long-lived plasma cell (LLPC) population is the sine qua non of durable antibody responses after vaccination or infection. We studied 20 individuals with a prior coronavirus disease 2019 infection and characterized the antibody response using bone marrow aspiration and plasma samples. We noted deficient generation of spike-specific LLPCs in the bone marrow after severe acute respiratory syndrome coronavirus 2 infection.
View Article and Find Full Text PDFJ Phys Chem B
May 2024
Department of Chemical Engineering, Istanbul Technical University, Istanbul 34469, Turkey.
The chemokine receptor CXCR4 is a critical target for the treatment of several cancer types and HIV-1 infections. While orthosteric and allosteric modulators have been developed targeting its extracellular or transmembrane regions, the intramembrane region of CXCR4 may also include allosteric binding sites suitable for the development of allosteric drugs. To investigate this, we apply the Gaussian Network Model (GNM) to the monomeric and dimeric forms of CXCR4 to identify residues essential for its local and global motions located in the hinge regions of the protein.
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