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Purpose: To compare the clinical outcomes, surgical workflow, and patient satisfaction following small incision lenticule extraction (SMILE) performed with the VisuMax 800 in one eye and the VisuMax 500 in the contralateral eye (both Carl Zeiss Meditec).
Methods: This was a prospective, single-site clinical study of patients undergoing SMILE for myopia and myopic astigmatism between February 2022 and August 2023. Each patient underwent bilateral treatment using the VisuMax 800 (VM800 group) in one eye and the VisuMax 500 (VM500 group) in the contralateral eye.
Predicting Antidepressant Treatment Response From Cortical Structure on MRI: A Mega-Analysis From the ENIGMA-MDD Working Group.
Hum Brain Mapp
January 2025
Amsterdam UMC, Department of Radiology and Nuclear Medicine, University of Amsterdam, Amsterdam, the Netherlands.
Accurately predicting individual antidepressant treatment response could expedite the lengthy trial-and-error process of finding an effective treatment for major depressive disorder (MDD). We tested and compared machine learning-based methods that predict individual-level pharmacotherapeutic treatment response using cortical morphometry from multisite longitudinal cohorts. We conducted an international analysis of pooled data from six sites of the ENIGMA-MDD consortium (n = 262 MDD patients; age = 36.
View Article and Find Full Text PDFOn the Tracks to "Smart" Single-Atom Catalysts.
J Am Chem Soc
January 2025
Department of Chemical and Pharmaceutical Sciences, Center for Energy, Environment and Transport Giacomo Ciamiciam, INSTM Trieste Research Unit and ICCOM-CNR Trieste Research Unit, University of Trieste, Via L. Giorgieri 134127Trieste, Italy.
Despite their enormous impact in modern heterogeneous catalysis, single-atom catalysts (SACs) continue to puzzle the catalysis community, which often struggles to draw correct conclusions in SAC-catalyzed experiments. In many cases, the reasons for such an uncertainty originate from the lack of knowledge of the exact single-atom evolution under operative conditions and the fundamental factors controlling the fate of the single atom in relation to the catalytic mechanism. This has led to confusion also about correct definition and terminology, where the coined term reflects the difficulty in defining the true active species as well as in obtaining long-range ordered homogeneous supports [Chi, S.
View Article and Find Full Text PDFAssociations of optic nerve head morphology and peripapillary retinal nerve fibre layer thickness with myopic severity and treatment in children.
Asia Pac J Ophthalmol (Phila)
December 2024
Singapore National Eye Centre, Singapore; Eye Academic Clinical Programme (ACP), Duke-NUS Graduate Medical School, Singapore. Electronic address:
Purpose: This study aimed to investigate the longitudinal associations between myopic optic disc features and optical coherence tomography (OCT) measurements of peripapillary retinal nerve fibre layer (RNFL) thickness in young myopic children in Singapore.
Methods: A prospective, single-site cohort study was conducted, involving children aged 7-16 years who participated in the PROM-Kids clinical cohort study from 2019 to 2022. Participants underwent annual assessments, including cycloplegic refraction, axial length measurements, fundus photography, and OCT imaging, with ocular magnification correction.
Objective: The purpose of this study was to evaluate the effectiveness of the drugs Solifenacin and Vesusten in relation to the treatment of neurogenic bladder overactivity in multiple sclerosis (MS).
Materials And Methods: A prospective, single-site, single-center, placebo-controlled, parallel-group, comparative clinical trial was conducted. The study included 41 MS patients of both sexes aged 18-50 years with urodynamically confirmed detrusor overactivity.
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