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in Native Americans in Northern Arizona. | LitMetric

in Native Americans in Northern Arizona.

Diseases

Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, 1295 N Martin Ave, Tucson, AZ 85724, USA.

Published: March 2022

Background: In Arizona prevalence of infection among Navajo adults is about 62% and gastric cancer incidence rate is 3-4 times higher than that of the non-Hispanic White population.

Aim: The aim of this study was to estimate the prevalence of specific virulence factors ( and ) among Navajo patients undergoing and their association with gastric disease.

Methods: Virulence genes, and in were investigated in gastric biopsies from 96 Navajo patients over age 18 who were undergoing esophagogastroduodenoscopy. Biopsies from the antrum and fundus were used for molecular characterization to determine type and number of EPIYA motifs and presence of alleles in the signal (s) and medium (m) regions of the gene.

Results: infection was found in 22.9% of the biopsy samples. The gene amplified in 57.6% of samples and showed a predominant "Western " type, with the EPIYA-ABC motif (45.4%), most prevalent. The allele s1bm1 was the most prevalent (54.5%).

Conclusions: genotypes were predominantly Western-type and ABC EPIYA motifs. The s1bm1 genotype was the most prevalent and seemed to be associated with gastritis. American Indian/Alaska Native populations are at higher risk for gastric cancer. It is important to identify genotypes of and virulence factors involved in the high prevalence of and associated disease among the Navajo population.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036257PMC
http://dx.doi.org/10.3390/diseases10020019DOI Listing

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