Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Background: In Arizona prevalence of infection among Navajo adults is about 62% and gastric cancer incidence rate is 3-4 times higher than that of the non-Hispanic White population.
Aim: The aim of this study was to estimate the prevalence of specific virulence factors ( and ) among Navajo patients undergoing and their association with gastric disease.
Methods: Virulence genes, and in were investigated in gastric biopsies from 96 Navajo patients over age 18 who were undergoing esophagogastroduodenoscopy. Biopsies from the antrum and fundus were used for molecular characterization to determine type and number of EPIYA motifs and presence of alleles in the signal (s) and medium (m) regions of the gene.
Results: infection was found in 22.9% of the biopsy samples. The gene amplified in 57.6% of samples and showed a predominant "Western " type, with the EPIYA-ABC motif (45.4%), most prevalent. The allele s1bm1 was the most prevalent (54.5%).
Conclusions: genotypes were predominantly Western-type and ABC EPIYA motifs. The s1bm1 genotype was the most prevalent and seemed to be associated with gastritis. American Indian/Alaska Native populations are at higher risk for gastric cancer. It is important to identify genotypes of and virulence factors involved in the high prevalence of and associated disease among the Navajo population.
Download full-text PDF |
Source |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9036257 | PMC |
http://dx.doi.org/10.3390/diseases10020019 | DOI Listing |
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