Two new cyclic lipopeptides, acuminatums E () and F (), together with four known cyclic lipopeptides, acuminatums A-D (-) were isolated from the corn culture of endophytic HU0053. Their structures were elucidated by spectroscopic and advanced Marfey's amino acid analysis. All compounds were found to exhibit antifungal activities against . Acuminatum F (), a new cyclic lipopeptide containing an unusual 3, 4-dihydroxy-phenylalanine unit exhibited the strongest antifungal activities with inhibition zone of 6.5 mm at the dose of 6.25 μg. Therefore, acuminatum F might be a potential environmental-friendly preservative for citrus fruits.
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