To evaluate whether selenium nanoparticles (SeNPs) can stimulate bone formation and inhibit the bone loss involved in hyperglycemia-induced osteoporosis. Rat osteoblastic UMR-106 cells were used for studies and female Sprague-Dawley rats were used for type 2 diabetes-associated osteoporosis study. studies show that SeNPs promote osteoblast differentiation via modulating alkaline phosphatase (ALP) activity, and promoting calcium nodule formation and collagen content. The authors also provide evidence regarding the involvement of the BMP-2/MAPKs/β-catenin pathway in preventing diabetic osteoporosis. Further, and studies suggested that SeNPs can preserve mechanical and microstructural properties of bone. To the best of our knowledge, this study provides the first evidence regarding the therapeutic benefits of SeNPs in preventing diabetes-associated bone fragility.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/nnm-2021-0401 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of Enterobacter cloacae extract, selenium nanoparticles and methyl jasmonate on shoot liquid cultures of Sarcocornia fruticosa under salinity stress.
BMC Plant Biol
January 2025
Department of Botany and Microbiology, Faculty of Science, Alexandria University, Alexandria, Egypt.
Background: The in vitro propagation of halophytes is innovative perspective for sustainable agriculture, conservation of natural plants and essential raw materials for industry due to increasing soil salinization and decreasing freshwater availability. Sarcocornia fruticosa, a halophytic plant, may hold promise for biosaline production systems and achieve bioactive products. Understanding the salt tolerance mechanisms of halophytes through elicitors can enhance the production of secondary metabolites, such as phenolics and flavonoids, under saline environment.
View Article and Find Full Text PDFMultifunctional layer-by-layer smart film with betalains and selenium nanoparticles for intelligent meat freshness monitoring and preservation.
Food Chem
January 2025
Laboratory of Agricultural and Food Biophysics, Institute of Biophysics, College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China; Laboratory of Muscle Biology and Meat Science, National Beef Cattle Improvement Center, College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China; Laboratory of Meat Quality Analysis and Products Development, Ningxia Xihaigu Institute of High-end Cattle Industry, Haiyuan, Ningxia 755299, China. Electronic address:
Multifunctional pH-responsive films were fabricated via layer-by-layer deposition of gelatin, chitosan, and carboxymethyl cellulose (CMC), incorporating selenium nanoparticles (SeNPs) and beetroot extract (BTE), to monitor and preserve beef freshness. SeNPs were synthesized and characterized via various techniques. BTE exhibited promising functional properties, and films demonstrated a significant color transition from red to yellow across pH 2-14.
View Article and Find Full Text PDFChitosan and alginate/Aspergillus flavus-mediated nanocomposite films for preservation of postharvest tomatoes.
Int J Biol Macromol
January 2025
Botany and Microbiology Department, Faculty of Science, Cairo University, Giza 12613, Egypt. Electronic address:
The isolated Aspergillus flavus NSRN22 was used for green synthesis of silver and selenium nanoparticles (AgNPs and SeNPs). New food packaging films produced by combining each type of NPs with chitosan (CS) or sodium alginate (SA) were characterized. Transmission electron microscopy revealed that the average particle size was lower in case of AgNPs (9 to 14.
View Article and Find Full Text PDFRecent research progress on the biological functions, synthesis and applications of selenium nanoparticles.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2025
Chongqing Key Laboratory of Reproductive Health and Digital Medicine, Department of Laboratory Medicine, Chongqing General Hospital, School of Medicine, Chongqing University, Chongqing 400044, China. Electronic address:
Selenium is an essential trace element that is involved in a variety of complex biological processes and has a significant positive effect on the prevention and treatment of cardiovascular disease, inflammatory diseases, and cancer. Selenium in the body is mainly provided by daily meals. However, selenium has two sides, beneficial in moderation and harmful in excess.
View Article and Find Full Text PDFDate seeds polysaccharides as novel capping agents for selenium nanoparticles: Synthesis, characterization, stability, biological activities, and gut microbiota modulation.
Food Chem
January 2025
Department of Food Science, College of Agriculture and Veterinary Medicine, United Arab Emirates University (UAEU), PO Box 15551, Al-Ain, United Arab Emirates. Electronic address:
Date seed polysaccharides were utilized to synthesize selenium nanoparticles (MPS-NP) through a redox reaction involving sodium selenite and ascorbic acid. Characterization of MPS-NP showed a uniform, amorphous, spherical shape with a particle size of 89.2 nm, remaining stable for 42 days.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!