AI Article Synopsis
- - Chronic inflammation from conditions like Crohn's disease can cause harmful mutations in hematopoietic stem cells, potentially leading to leukemia.
- - A case study highlighted a patient who developed acute promyelocytic leukemia (APL) at 51 after living with chronic Crohn's disease since age 28, despite receiving some treatments.
- - The findings suggest that ongoing inflammation in Crohn's disease may increase the risk of genomic instability in stem cells, making APL a serious concern for these patients.
Article Abstract
Chronic inflammation can induce leukemogenic mutations in hematopoietic stem cells (HSCs). We report a case of acute promyelocytic leukemia (APL) in a patient with chronic continuous type of Crohn's disease. The patient had been diagnosed with Crohn's disease at the age of 28 years and had received conventional treatments with biologics, but not azathioprine. At the age of 51, he was diagnosed with APL with ider(17). Long-term exposure to chronic continuous inflammation from Crohn's disease might be a factor inducing genomic instability in HSCs, which lead to the subsequent development of APL. APL is a rare hematological manifestation that required attention in Crohn's disease patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993430 | PMC |
| http://dx.doi.org/10.14740/jocmr4675 | DOI Listing |
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