Rosacea granulomatosis is a common, chronic skin disorder that primarily affects the central face, namely the cheek, nose, chin, and central forehead. Although rosacea is mainly a disorder of innate and adaptive immunity, a variety of endogenous and exogenous triggers such as may stimulate it. Often found as commensal organisms in human skin, ​​​​​​​can be parasitic if there is a change in the host's cutaneous environment. This is especially relevant for immunosuppressed patients, who need prompt treatment to prevent further complications. We review the literature regarding rosacea granulomatosis in immunosuppression and present an acute myelogenous leukemia patient with severe neutropenia, which may have promoted the development of rosacea due to ​​​​​​​mite proliferation. This local proliferation of the ectoparasite on the face can cause an atypical skin rash that mimics severe infections in the setting of neutropenia.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9015070PMC
http://dx.doi.org/10.7759/cureus.23308DOI Listing

Publication Analysis

Top Keywords

rosacea granulomatosis
12
rosacea
5
granulomatosis neutropenic
4
neutropenic leukemic
4
leukemic patient
4
patient rosacea
4
granulomatosis common
4
common chronic
4
chronic skin
4
skin disorder
4

Similar Publications

Rosacea granulomatosis is a common, chronic skin disorder that primarily affects the central face, namely the cheek, nose, chin, and central forehead. Although rosacea is mainly a disorder of innate and adaptive immunity, a variety of endogenous and exogenous triggers such as may stimulate it. Often found as commensal organisms in human skin, ​​​​​​​can be parasitic if there is a change in the host's cutaneous environment.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to identify patients with recurrent orofacial swelling and assess various causes to establish a diagnostic approach.
  • It analyzed 104 patients with multiple episodes of swelling lasting over 5 days from 2000 to 2011, categorizing the causes into several medical conditions like Crohn disease, rosacea, and others.
  • Results showed that granulomatous inflammation was evident in nearly half the patients, highlighting the need for careful evaluation by multiple specialties to determine the cause of the swelling.
View Article and Find Full Text PDF

Orofacial granulomatosis.

Clin Dermatol

May 2017

Department of Dermatology, Mayo Clinic, Scottsdale, AZ.

Orofacial granulomatosis (OFG) is an uncommon chronic granulomatous condition with a multifactorial etiology and pathogenesis. Genetic, immunologic, allergic, and infectious mechanisms have been implicated. OFG is often used as a descriptor to encompass all entities with orofacial swelling and histologic evidence of noncaseating granulomas.

View Article and Find Full Text PDF

Tumor necrosis factor-alpha (TNF)-alpha inhibitors are licensed for patients with severe refractory psoriasis and psoriatic arthritis. However, TNF-alpha inhibitors have also been used off-label for various recalcitrant mucocutaneous diseases. This study aimed to evaluate the efficacy and safety of TNF-alpha inhibitors used for off-label dermatological indications.

View Article and Find Full Text PDF

The granulomatous inflammation seen in filariasis, orofacial granulomatosis (OFG), rosacea and sarcoidosis can be associated with lymphoedema. In the setting of OFG, the finding of intralymphatic granulomas has been reported as a possible mechanism for lymphoedema. Anogenital granulomatosis (AGG) is a similar chronic inflammatory condition of unknown pathogenesis.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!