The gene has been elucidated to govern the development of chronic granulocytic leukemia (CGL). Moreover, it has been suggested that the levels of in circulation are affected by the rs4946936 gene polymorphism. However, no study has assessed the correlation between the rs4946936 gene polymorphism and the levels of . The objective of this study was to assess the association between the rs4946936 gene polymorphism and the levels of in CGL patients treated with imatinib mesylate. A cross-sectional study was conducted from February 2019 to February 2020. The genotyping of rs4946936 gene polymorphism was conducted using PCR-RFLP, and the levels of were assessed using ELISA. The association between the rs4946936 gene polymorphism and the levels of were assessed using multiple logistic regression. A total of 60 CGL patients were assessed in our study. Among them, the CC, CT, and TT genotypes of the rs4946936 gene polymorphism were 35.0%, 48.3%, and 16.7% respectively. Our calculation revealed that elevated levels of were found in CGL patients with the CC genotype of the rs4946936 gene polymorphism. While we failed to clarify the association between either the CT or the TT genotype of rs4946936 gene polymorphism and the levels of . Our study identifies that the CC genotype of the rs4946936 gene polymorphism affects the elevated levels of in CGL patients treated with imatinib mesylate.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9005988 | PMC |
| http://dx.doi.org/10.12688/f1000research.73054.3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association of NOS2A Gene Polymorphisms with Susceptibility to Tuberculosis in Manipuri Population of Northeast India.
Biochem Genet
January 2025
Department of Biotechnology, Manipur University, Canchipur, Imphal, 795003, Manipur, India.
Single nucleotide polymorphisms (SNPs) have been reported to influence the activity of specific genes involved with the innate immune response to Mycobacterium; hence, they are crucial in tuberculosis (TB) susceptibility studies. The study aimed to investigate the polymorphism in the NOS2A (Nitric oxide synthase 2A) gene and its association with susceptibility to TB in the Manipuri population of northeast India. This case-control study includes 495 subjects- 220 TB patients and 275 control individuals.
View Article and Find Full Text PDFAssociation Among rs1049434 Polymorphism, Athlete Status, and Physiological Parameters in Japanese Long-Distance Runners.
Genes (Basel)
December 2024
Faculty of Sport Science, Nippon Sport Science University, 7-1-1, Fukasawa, Setagaya-ku 158-8508, Japan.
Background/objectives: Monocarboxylate transporters (MCTs) comprise 14 known isoforms, with MCT1 being particularly important for lactate transport. Variations in lactate metabolism capacity and aerobic performance are associated with the T1470A polymorphism in . We aimed to investigate the frequency of the T1470A polymorphism and compare relevant physiological parameters among long-distance runners, wherein these parameters are fundamental to athletic performance.
View Article and Find Full Text PDFICAM-1 K469E gene polymorphism, genotype-phenotype correlation, and retinopathy in Type 2 diabetes mellitus patients.
Ophthalmic Genet
January 2025
Department of Ophthalmology, PSG Institute of Medical Sciences and Research, Coimbatore, India.
Context: The role of genetic factors in the development of diabetic retinopathy is evident from the fact that only 50% of patients with the non-proliferative type of diabetic retinopathy progress to proliferative diabetic retinopathy. Though the K469E polymorphism of the ICAM-1 (Intercellular Adhesion Molecule-1) gene is known to increase the risk of developing Diabetic Retinopathy (DR) among Type 2 diabetic patients, its role in the development of severe DR has not been extensively studied.
Aim: Hence, we aimed to determine the risk due to association of K469E polymorphism of ICAM-1 gene and sight threatening diabetic retinopathy.
Association of vitamin D receptor gene polymorphisms, metabolic features and susceptibility to polycystic ovary syndrome: a preliminary study.
Reprod Biomed Online
September 2024
UMF Iuliu Haţieganu, Cluj-Napoca, Romania.
Research Question: Are the combined genotypes and haplotypes of vitamin D receptor (VDR) gene polymorphisms (FokI, ApaI and TaqI) associated with susceptibility to polycystic ovary syndrome (PCOS) and metabolic features of the disease?
Design: This case-control study included 46 women with PCOS and 48 controls. Genotypes of the VDR gene were determined using the polymerase chain reaction-restriction fragment length polymorphism method. Waist circumference, and parameters of lipid and glucose metabolism were evaluated in all women.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!