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Background: Axial Spondyloarthritis (axSpA) is a chronic inflammatory rheumatic condition affecting the axial skeleton, leading to pain, stiffness, and fatigue. While biologic therapies have improved clinical management, many patients experience partial or no responses, resulting in delays in disease control. Additionally, the risk of adverse events and increased costs remains a concern.
View Article and Find Full Text PDFMechanisms of resistance to cell wall and plasma membrane targeting antifungal drugs in candida species isolated in africa.
Expert Rev Anti Infect Ther
January 2025
Pathogenic Yeast Research Group, Department of Microbiology and Biochemistry, University of the Free State, Bloemfontein, South Africa.
Introduction: There is a rise in antifungal resistance as well as the emergence of multidrug resistant fungal pathogens worldwide, including in Africa.
Method: This systematic review summarized the published data on the mechanisms and epidemiology of antifungal resistance in species in Africa between 2000 and early 2024.
Result: Seventeen reports from seven African countries were analyzed but due to the paucity of data, the prevalence of antifungal resistant isolates in Africa could not be estimated.
A subcellular sampling instrument allows spatial resolution of amyloid deposit-derived organelle-specific effects in microglia.
Commun Biol
January 2025
Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Methodological developments in biomedical research are currently moving towards single-cell approaches. This allows for a much better spatial and functional characterization of, for example, the deterioration of cells within a tissue in response to noxae. However, subcellular resolution is also essential to elucidate whether observed impairments are driven by an explicit organelle.
View Article and Find Full Text PDFUse of Remote Regulatory Assessment (RRA) for Site Evaluations during the COVID-19 Pandemic: The USFDA's Office of Study Integrity and Surveillance (OSIS) Perspective.
AAPS PharmSciTech
January 2025
OSIS, Silver Spring, Maryland, U.S.A.
Travel restrictions during the novel coronavirus, SARS-CoV-2 (COVID-19) public health emergency affected the U.S. Food and Drug Administration's (FDA) ability to conduct on-site bioavailability/bioequivalence (BA/BE) and Good Laboratory Practice (GLP) nonclinical inspections.
View Article and Find Full Text PDFThe association between perceived student gratitude and teacher family role performance: A moderated mediation model.
Acta Psychol (Amst)
January 2025
College of Arts and Media YunNan College of Business Management, Qilin Road, KunMing, PR China.
Objective: In recent years, numerous studies have highlighted the positive impact of student gratitude on individual development. However, a significant gap remains in the literature concerning how student gratitude influences teachers' family behavioral performance in their daily lives. This paper introduces Conservation of Resources (COR) Theory to examine the mediating effect of work-family enrichment on the relationship between student gratitude and teachers' family role performance, while also investigating whether intrinsic motivation moderates this relationship.
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