AI Article Synopsis
- Many cellular signaling pathways play a crucial role in regulating important processes such as cell growth, movement, and programmed cell death, and their disruption can lead to cancer development and progression.
- Recent research has highlighted the potential of natural products, like quercetin—a flavonol found in everyday foods—as effective agents in cancer treatment due to their ability to inhibit tumor growth through various mechanisms.
- This summary focuses on the therapeutic benefits of quercetin specifically in gastrointestinal cancers, including pancreatic, gastric, colorectal, esophageal, hepatocellular, and oral cancers.
Article Abstract
Many cellular signaling pathways contribute to the regulation of cell proliferation, division, motility, and apoptosis. Deregulation of these pathways contributes to tumor cell initiation and tumor progression. Lately, significant attention has been focused on the use of natural products as a promising strategy in cancer treatment. Quercetin is a natural flavonol compound widely present in commonly consumed foods. Quercetin has shown significant inhibitory effects on tumor progression various mechanisms of action. These include stimulating cell cycle arrest or/and apoptosis as well as its antioxidant properties. Herein, we summarize the therapeutic effects of quercetin in gastrointestinal cancers (pancreatic, gastric, colorectal, esophageal, hepatocellular, and oral).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019477 | PMC |
| http://dx.doi.org/10.3389/fphar.2022.860209 | DOI Listing |
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