A methodology to learn acoustical responses based on limited experimental datasets is presented. From a methodological standpoint, the approach involves a multiscale-informed encoder used to cast the learning task in a finite-dimensional setting. A neural network model mapping parameters of interest to the latent variables is then constructed and calibrated using transfer learning and knowledge gained from the multiscale surrogate. The relevance of the approach is assessed by considering the prediction of the sound absorption coefficient for randomly-packed rigid spherical beads of equal diameter. A two-microphone method is used in this context to measure the absorption coefficient on a set of configurations with various monodisperse particle diameters and sample thicknesses, and a hybrid numerical approach relying on the Johnson-Champoux-Allard-Pride-Lafarge model is deployed as the multiscale-based predictor. It is shown that the strategy allows for the relationship between the micro-/structural parameters and the experimental acoustic response to be well approximated, even if a small physical dataset (comprised of ten samples) is used for training. The methodology, therefore, enables the identification and validation of acoustical models under constraints related to data limitation and parametric dependence. It also paves the way for an efficient exploration of the parameter space for acoustical materials design.
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http://dx.doi.org/10.1121/10.0010187 | DOI Listing |
Am J Emerg Med
January 2025
Department of Emergency Medicine, Yale University School of Medicine, New Haven, CT, USA; Center for Outcomes Research and Evaluation, Yale University, New Haven, CT, USA.
Background: This study aimed to examine how physician performance metrics are affected by the speed of other attendings (co-attendings) concurrently staffing the ED.
Methods: A retrospective study was conducted using patient data from two EDs between January-2018 and February-2020. Machine learning was used to predict patient length of stay (LOS) conditional on being assigned a physician of average speed, using patient- and departmental-level variables.
Proc Natl Acad Sci U S A
January 2025
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139.
Protein language models (PLMs) have demonstrated impressive success in modeling proteins. However, general-purpose "foundational" PLMs have limited performance in modeling antibodies due to the latter's hypervariable regions, which do not conform to the evolutionary conservation principles that such models rely on. In this study, we propose a transfer learning framework called Antibody Mutagenesis-Augmented Processing (AbMAP), which fine-tunes foundational models for antibody-sequence inputs by supervising on antibody structure and binding specificity examples.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Physics, The Hong Kong University of Science and Technology, Hong Kong, China.
Dissolution of CO in water followed by the subsequent hydrolysis reactions is of great importance to the global carbon cycle, and carbon capture and storage. Despite numerous previous studies, the reactions are still not fully understood at the atomistic scale. Here, we combined ab initio molecular dynamics (AIMD) simulations with Markov state models to elucidate the reaction mechanisms and kinetics of CO in supercritical water both in the bulk and nanoconfined states.
View Article and Find Full Text PDFJMIR Med Inform
January 2025
Department of Science and Education, Shenzhen Baoan Women's and Children's Hospital, Shenzhen, China.
Background: Large language models (LLMs) have been proposed as valuable tools in medical education and practice. The Chinese National Nursing Licensing Examination (CNNLE) presents unique challenges for LLMs due to its requirement for both deep domain-specific nursing knowledge and the ability to make complex clinical decisions, which differentiates it from more general medical examinations. However, their potential application in the CNNLE remains unexplored.
View Article and Find Full Text PDFJMIR AI
January 2025
Department of Radiology, Children's National Hospital, Washington, DC, United States.
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