Background: Angelica gigas Nakai is used as an herbal pharmaceutical material in Korea.
Aims: To investigate the anti-wrinkle effects of A. gigas Nakai root extracts (ARE) using mineral-rich water in in vitro and clinical trials.
Materials And Methods: The cell viability of ARE was evaluated using a water-soluble tetrazolium salt assay. After evaluating ARE's cytotoxicity, we used an enzyme-linked immunosorbent assay kit to assess the effects of ARE on type I collagen in human dermal fibroblasts (HDFs). During a double-blinded in vivo clinical study, participants were randomly assigned to use the sample and placebo formulations for the left and right sides of their face over an 8-week period. We evaluated the anti-wrinkle properties of the formulations using PRIMOS Lite and a global photodamage score.
Results: A. gigas Nakai root extracts cytotoxicity was evaluated in HDFs. We demonstrate that ARE increased type I collagen production by 40% at 50 μg/ml as compared with the control. The use of an ARE lotion significantly reduced the presence of crow's feet wrinkles in comparison with the use of the placebo after 8 weeks. Additionally, use of the ARE lotion led to decreased photodamage scores, indicating anti-wrinkle effects.
Conclusion: The use of ARE with mineral-rich water has anti-wrinkle effects in in vitro and clinical trials.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084234 | PMC |
| http://dx.doi.org/10.1111/jocd.15017 | DOI Listing |
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