Testing is an important part of the design flow in the semiconductor industry. Unfortunately, it also consumes up to half of the production cost. On-silicon stimulus generators and response analyzers can be integrated with the Device-Under-Test (DUT) to reduce production costs with a minimum increment in power and area consumption. This practice is known as the Built-In Self-Test (BIST). This work presents a single-tone generator for BIST applications that is based on the Harmonic-Canceling (HC) technique. The main idea is to cancel or filter out the harmonics of a square-wave signal in order to obtain a highly pure sine wave. The design challenges of this technique are the precise implementation of irrational coefficients in silicon and the strong dependence of the output's linearity on the coefficients' precision. In order to reduce this dependence, this work introduces an irrational coefficient generator that is based on the recursive use of special matrices called skew-circulant matrices (SCMs). A complete study of the SCM-based HC synthesizer, its properties, and the proposed implementation in 180 nm CMOS technology are presented. The measured results show that the proposed HC synthesizer is able to filter out up to the 47th harmonic of a given square wave and to generate signals from 0.8 to 100 MHz with a maximum Spurious-Free Dynamic Range (SFDR) of 66 dB.
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http://dx.doi.org/10.3390/s22082884 | DOI Listing |
Biosens Bioelectron
January 2025
Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, Barcelona, 08193, Spain; Catalan Institution for Research and Advanced Studies (ICREA) Passeig de Lluís Companys, 23, Barcelona, 08010, Spain. Electronic address:
Quantum dots (QDs) are the smallest nanomaterials (2-10 nm), with unique optical and electronic properties. Thanks to these properties, QDs have been standing during the last years as signal tags for different applications, including bioimaging, fluorescent biosensors and electrochemical assays. In this review, we explore the current state-of-the art on these nanomaterials, differentiating them between semiconductor and carbon-based QDs.
View Article and Find Full Text PDFCytotherapy
January 2025
Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain. Electronic address:
Background/aims: Human mesenchymal stromal cells (hMSC) are multipotent adult cells commonly used in regenerative medicine as advanced therapy medicinal products. The expansion of these cells in xeno-free supplements is highly encouraged by regulatory agencies due to safety concerns. However, the number of supplements with robust performance and consistency for hMSC expansion are limited.
View Article and Find Full Text PDFPolymers (Basel)
January 2025
Departamento de Ciencias Preclínicas, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile.
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a well-known technique for polymer analysis, particularly for determining the molecular weight and structural details of dendrimers. In this study, we evaluated the performance of various matrices, such as 2',4',6'-trihydroxyacetophenone (THAP), α-cyano-4-hydroxycinnamic acid (HCCA), and sinapinic acid (SA), and their combinations, on the sensitivity and resolution of poly(amidoamine) (PAMAM) dendrimers of different generations (G3.0, G4.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
Department of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn Str. 6, 44227 Dortmund, Germany.
Dynamically interconvertible metallo-supramolecular multicomponent assemblies, coexisting orthogonally in solution, serve as simplified mimics for complex networks found in biological systems. Building on recent advances in controlling the nonstatistical self-assembly of heteroleptic coordination cages and heteromeric completive self-sorting, i.e.
View Article and Find Full Text PDFAnal Chem
January 2025
Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), 08028 Barcelona, Spain.
Nuclear magnetic resonance (NMR) spectroscopy is a valuable diagnostic tool limited by low sensitivity due to low nuclear spin polarization. Hyperpolarization techniques, such as dissolution dynamic nuclear polarization, significantly enhance sensitivity, enabling real-time tracking of cellular metabolism. However, traditional high-field NMR systems and bioreactor platforms pose challenges, including the need for specialized equipment and fixed sample volumes.
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