A diastereoselective synthesis of the β-anomer of glycinamide ribonucleotide (β-GAR) has been developed. The synthesis was accomplished in nine steps from D-ribose and occurred in 5% overall yield. The route provided material on the multi-milligram scale. The synthetic β-GAR formed was remarkably resistant to anomerization both in solution and as a solid.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024515 | PMC |
| http://dx.doi.org/10.3390/molecules27082528 | DOI Listing |
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