A series of regioisomers of the hydroxystearic acid () was prepared, and the effect of the position of the hydroxyl group along the chain on a panel of human cancer cell lines was investigated. Among the various regioisomers, those carrying the hydroxyl at positions 5, 7, and 9 had growth inhibitor activity against various human tumor cell lines, including CaCo-2, HT29, HeLa, MCF7, PC3, and NLF cells. and showed a very weak effect. did not show inhibitory activity in all cell lines. The biological role of and is widely recognized, while little is known about the effects of . Therefore, the biological effects of in HeLa, HT29, MCF7, and NLF cell lines were investigated using the Livecyte's ptychography technology, which allows correlating changes in proliferation, motility, and morphology as a function of treatment at the same time. not only reduces cell proliferation but also induces changes in cell displacement, directionality, and speed. It is important to characterize the biological effects of , this molecule being an important component of fatty acyl esters of hydroxy fatty acids (FAHFA), a class of endogenous mammalian lipids with noticeable anti-diabetic and anti-inflammatory effects.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029951 | PMC |
| http://dx.doi.org/10.3390/molecules27082396 | DOI Listing |
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