Biomonitoring of Urinary Nickel Successfully Protects Employees and Introduces Effective Interventions.

Int J Environ Res Public Health

Division of Occupational Medicine, Department of Emergency, Taichung Veterans General Hospital, Taichung 40705, Taiwan.

Published: April 2022

AI Article Synopsis

  • Nickel is a heavy metal linked to respiratory diseases, allergies, and increased cancer risk, prompting a study on how to reduce worker exposure in a faucet manufacturing plant.
  • A controlled study was conducted from 2018 to 2019 involving 37 male workers categorized by their nickel exposure, with results from environmental monitoring and biomonitoring collected before and after a new grinding and polishing system was introduced.
  • The intervention showed significant reductions in urinary nickel concentrations, indicating that the new system and educational program were effective in lowering exposure levels among workers.

Article Abstract

Nickel is a heavy metal used in many industries. Nickel exposure can induce respiratory diseases and allergic reactions, and increase cancer risk. This study evaluated the introduction of a grinding and polishing system to prevent injuries from nickel toxicity in workers. We performed a controlled, interventional, before-and-after study from January 2018 to December 2019 at a faucet component industrial manufacturing site. Results from workplace environmental monitoring, questionnaire responses, and biomonitoring were collected before and after the intervention. Thirty-seven workers (100% men) aged 25.0 (interquartile range (IQR): 22.0-33.5) years were categorized into two groups, those with and without nickel exposure. In the exposed group, the median exposure time was 18.0 months (IQR 14.0-20.0 months). Urinary nickel concentration was lower in the exposed group than in the non-exposed group (13.8 (IQR 1.7-20.7); 23.1 (IQR 11.3-32.8) μg/g creatinine, respectively; = 0.047). The median urinary nickel concentration was lower in the second year than in the first year (17.4 (IQR 2.2-27.4), 7.7 (IQR 4.3-18.5) μg/g creatinine, respectively; = 0.022). Significant reductions in urinary nickel concentration were observed following the intervention and educational program. Thus, biomonitoring of urinary nickel concentration can successfully reflect the effectiveness of interventions and their relationship to nickel exposure.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032121PMC
http://dx.doi.org/10.3390/ijerph19084887DOI Listing

Publication Analysis

Top Keywords

urinary nickel
20
nickel concentration
16
nickel exposure
12
nickel
10
biomonitoring urinary
8
exposed group
8
concentration lower
8
μg/g creatinine
8
iqr
6
nickel protects
4

Similar Publications

Objective: The aim was to evaluate the sustainability of the pancreatic Enhanced Recovery After Surgery (ERAS) program and the effect of ERAS items on patient morbidity and hospital stay.

Background: The current ERAS guideline recommendations encompass 27 items to improve recovery after pancreatoduodenectomy (PD).

Methods: Patients who underwent pancreatic resection at the University Hospital Hamburg-Eppendorf between February 2016 and June 2023 were included.

View Article and Find Full Text PDF

Introduction: The balance of trace elements plays an important role in diabetic kidney disease (DKD) patients. However, studies on the differences in urinary trace elements across different DKD stages are scarce. This study aimed to explore the associations between nine essential trace elements and DKD.

View Article and Find Full Text PDF

Exposure to multiple metals and leukocyte telomere length in children and adolescents: The mediating effect of thyroid hormones.

Environ Res

January 2025

Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Key Laboratory of Environment and Health, Ministry of Education, And State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address:

Exposure to metals has been related to alterations in leukocyte telomere length (LTL), an aging marker. However, the evidence regarding this relationship in children and adolescents, as well as the underlying mechanisms, remains unclear. Therefore, we aimed to explore the individual and mixture effects of metals on LTL in children and adolescents and to assess the mediating role of thyroid hormones and the modifying effect of a healthy lifestyle.

View Article and Find Full Text PDF

Objective: The results of epidemiological studies on the association between nickel exposure and diabetes remain controversial. Therefore, an update meta-analysis was conducted to examine the association between urinary nickel levels and diabetes risk, and to focus on whether there is an association between blood nickel levels and diabetes risk.

Methods: Relevant studies were comprehensively searched from PubMed, Web of Science, and Wanfang databases from their inception to July 2024.

View Article and Find Full Text PDF

Metallomic analysis of urine from individuals with and without Covid-19 infection reveals extensive alterations in metal homeostasis.

J Trace Elem Med Biol

December 2024

Institute of Chemistry, University of Campinas - Unicamp, PO Box 6154, Campinas, SP 13083-970, Brazil; National Institute of Science and Technology for Bioanalytics, Institute of Chemistry, University of Campinas - Unicamp, PO Box 6154, Campinas, SP 13083-970, Brazil. Electronic address:

Background: Metal ions perform important functions in the body and their concentrations in cells and tissues are tightly controlled. Alterations in metal homeostasis can occur in certain disease states including infection. In this study urinary excretion of several metals including calcium, cadmium, cobalt, copper, iron, magnesium, nickel, selenium, and zinc in Covid-19 patients (n=35) and control (n=60) individuals, spanning ages and sexes.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: