AI Article Synopsis
- Spitz neoplasms are a diverse group of skin tumors with varying histological traits and biological behaviors, making classification complex.
- Recent research has identified distinct subtypes through specific genetic mutations and alterations, aiding in precise tumor classification.
- Understanding these molecular characteristics allows for better diagnosis and identification of aggressive subtypes that may need further analysis.
Article Abstract
Spitz neoplasms are a heterogeneous group of melanocytic proliferations with a great variability in the histological characteristics and in the biological behavior. Thanks to recent discoveries, the morpho-molecular landscape of Spitz lineage is becoming clearer, with the identification of subtypes with recurrent features thus providing the basis for a more solid and precise tumor classification. Indeed, specific mutually exclusive driver molecular events, namely or mutations, copy number gains of 11p, and fusions involving and genes, correlate with distinctive histological features. The accumulation of further molecular aberrations, instead, promotes the increasing malignant transformation of Spitz neoplasms. Thus, the detection of a driver genetic alteration can be achieved using the appropriate diagnostic tests chosen according to the histological characteristics of the lesion. This allows the recognition of subtypes with aggressive behavior requiring further molecular investigations. This review provides an update on the morpho-molecular correlations in Spitz neoplasms.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9030540 | PMC |
| http://dx.doi.org/10.3390/ijms23084211 | DOI Listing |
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