AI Article Synopsis
- Intestinal alkaline phosphatase (IALP) is significant for its role in preventing and treating diseases linked to leaky gut by maintaining intestinal microbial balance and barrier function.
- IALP helps dephosphorylate lipopolysaccharides, which is crucial for proper gut health and may influence conditions like inflammatory bowel disease, necrotizing enterocolitis, and metabolic syndrome.
- The review explores IALP as a potential biomarker for assessing intestinal health and examines approaches to enhance IALP activity.
Article Abstract
Intestinal alkaline phosphatase (IALP) has recently assumed a special relevance, being the subject of study in the prevention and treatment of certain diseases related to leaky gut. This brush border enzyme (ecto-enzyme) plays an important role in the maintenance of intestinal microbial homeostasis and intestinal barrier function through its ability to dephosphorylate lipopolysaccharide (LPS). This review addresses how IALP and intestinal barrier dysfunction may be implicated in the pathophysiology of specific diseases such as inflammatory bowel disease, necrotizing enterocolitis, and metabolic syndrome. The use of IALP as a possible biomarker to assess intestinal barrier function and strategies to modulate IALP activity are also discussed.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9026380 | PMC |
| http://dx.doi.org/10.3390/microorganisms10040746 | DOI Listing |
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