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Acute liver failure caused by occupational exposure to HCFC-123: Two case reports.
Medicine (Baltimore)
March 2019
Department of Medicine.
Rationale: Hydrochlorofluorocarbon 123 (HCFC-123, Freon123; 2,2-dichloro-1,1,1-trifluoroethane) has been widely used in refrigeration and heat-transfer applications as a substitute for chlorofluorocarbons due to its lower ozone-depleting potentials. Occupational exposure to HCFC-123 may cause mild reversible hepatoxicity, but no fatal cases have been reported yet.
Patient Concerns: In this report, we present cases of severe hepatitis with fatal outcome by HCFC-123.
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