Introduction: Surgically treated acute type A aortic dissection (ATAAD) patients are often restricted from physical exercise due to a lack of knowledge about safe blood pressure (BP) ranges. The aim of this study was to describe the evolution of early postoperative cardiac rehabilitation (CR) for patients with ATAAD.
Methods: This is a retrospective study of 73 patients with ATAAD who were referred to the CR department after surgery. An incremental symptom-limited exercise stress test (ExT) on a cyclo-ergometer was performed before and after CR, which included continuous training and segmental muscle strengthening (five sessions/week). Systolic and diastolic blood pressure (SBP and DBP) were monitored before and after all exercise sessions.
Results: The patients (78.1% male; 62.2 ± 12.7 years old; 54.8% hypertensive) started CR 26.2 ± 17.3 days after surgery. During 30.4 ±11.6 days, they underwent 14.5 ± 4.7 sessions of endurance cycling training, and 11.8 ± 4.3 sessions of segmental muscle strengthening. At the end of CR, the gain of workload during endurance training and functional capacity during ExT were 19.6 ± 10.2 watts and 1.2 ± 0.6 METs, respectively. The maximal BP reached during endurance training was 143 ± 14/88 ± 14 mmHg. The heart rate (HR) reserve improved from 20.2 ± 13.9 bpm to 33.2 ± 16.8 bpm while the resting HR decreased from 86.1 ± 17.4 bpm to 76.4 ± 13.3 bpm.
Conclusion: Early post-operative exercise-based CR is feasible and safe in patients with surgically treated ATAAD. The CR effect is remarkable, but it requires a close BP monitoring and supervision by a cardiologist and physical therapist during training.
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http://dx.doi.org/10.3390/jcm11082107 | DOI Listing |
J Med Internet Res
January 2025
Chronic Disease Epidemiology, Population and Public Health, Pennington Biomedical Research Center, Baton Rouge, LA, United States.
Background: Electronic health records (EHRs) facilitate the accessibility and sharing of patient data among various health care providers, contributing to more coordinated and efficient care.
Objective: This study aimed to summarize the evolution of secondary use of EHRs and their interoperability in medical research over the past 25 years.
Methods: We conducted an extensive literature search in the PubMed, Scopus, and Web of Science databases using the keywords Electronic health record and Electronic medical record in the title or abstract and Medical research in all fields from 2000 to 2024.
Clin Transl Gastroenterol
December 2024
Division of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Introduction: The utility of serial procalcitonin (PCT) measurements in cirrhotic patients with systemic inflammatory response syndrome (SIRS) is not well understood. This study aimed to assess the effectiveness of serial PCT measurements for diagnosing bacterial infections and predicting 30-day mortality in this population.
Methods: We prospectively studied 120 cirrhotic patients with SIRS, 64.
PLoS One
January 2025
Origin of Language Laboratories, School of Communication Sciences and Disorders, University of Memphis, Memphis, Tennessee, United States of America.
Speculations on the evolution of language have invoked comparisons across human and non-human primate communication. While there is widespread support for the claim that gesture plays a central, perhaps a predominant role in early language development and that gesture played the foundational role in language evolution, much empirical information does not accord with the gestural claims. The present study follows up on our prior work that challenged the gestural theory of language development with longitudinal data showing early speech-like vocalizations occurred more than 5 times as often as gestures in the first year of life.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Prehistory, Institute of Archaeology, Hebrew University of Jerusalem, Jerusalem, Israel.
The evolution of human behaviour is marked by key decision-making processes reflected in technological variability in the early archaeological record. As part of the technological system, differences in raw material quality directly affect the way that humans produce, design and use stone tools. The selection, procurement and use of various raw materials requires decision-making to evaluate multiple factors such as suitability to produce and design tools, but also the materials' efficiency and durability in performing a given task.
View Article and Find Full Text PDFPLoS Comput Biol
January 2025
Complex Systems Research Center, Shanxi University, Taiyuan, Shanxi, China.
Human mobility between different regions is a major factor in large-scale outbreaks of infectious diseases. Deep learning models incorporating infectious disease transmission dynamics for predicting the spread of multi-regional outbreaks due to human mobility have become a hot research topic. In this study, we incorporate the Graph Transformer Neural Network and graph learning mechanisms into a metapopulation SIR model to build a hybrid framework, Metapopulation Graph Transformer Neural Network (M-Graphormer), for high-dimensional parameter estimation and multi-regional epidemic prediction.
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