AI Article Synopsis
- Cardiovascular disease is becoming more common in hemophiliacs, largely due to their aging population, and they face risks from both bleeding and ischemic issues.
- Atrial fibrillation (AF) treatment is complex for hemophiliacs since it typically requires anticoagulants, and the CHADS-VASc score helps assess stroke risk to inform treatment options.
- Recent findings highlight effective strategies like catheter ablation and left atrial appendage occlusion for managing AF in hemophiliacs, especially if their bleeding risks are managed with appropriate therapy.
Article Abstract
Cardiovascular disease in hemophiliacs has an increasing prevalence due to the aging of this population. Hemophiliacs are perceived as having a high bleeding risk due to the coagulation factor VIII/IX deficiency, but it is currently acknowledged that they also have an important ischemic risk. The treatment of atrial fibrillation (AF) is particularly challenging since it usually requires anticoagulant treatment. The CHADS-VASc score is used to estimate the risk of stroke and peripheral embolism, and along with the severity of hemophilia, guide the therapeutic strategy. Our work provides the most complete, structured, and updated analysis of the current therapeutic approach of AF in hemophiliacs, emphasizing that there is a growing interest in therapeutic strategies that allow for short-term anticoagulant therapy. Catheter ablation and left atrial appendage occlusion have proven to be efficient and safe procedures in hemophiliacs, if appropriate replacement therapy can be provided.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9029474 | PMC |
| http://dx.doi.org/10.3390/jpm12040519 | DOI Listing |
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