AI Article Synopsis
- This study focused on using MRI to analyze brain injuries in newborns who experienced hypoxic-ischemic events, aiming to improve understanding and prognostication in clinical settings.
- Out of 794 infants, 520 were analyzed, with 52.4% showing brain injuries predominantly in the basal ganglia, white matter, and cortex, particularly noted in those scanned before 6 days of life.
- Findings highlight that identifying specific locations and types of brain injuries can help understand their mechanisms and timing, potentially guiding future treatment and prevention strategies.
Article Abstract
Background: Brain magnetic resonance imaging (MRI) is a key tool for the prognostication of encephalic newborns in the context of hypoxic-ischemic events. The purpose of this study was to finely characterize brain injuries in this context.
Methods: We provided a complete, descriptive analysis of the brain MRIs of infants included in the French national, multicentric cohort LyTONEPAL.
Results: Among 794 eligible infants, 520 (65.5%) with MRI before 12 days of life, grade II or III encephalopathy and gestational age ≥36 weeks were included. Half of the population had a brain injury (52.4%); MRIs were acquired before 6 days of life among 247 (47.5%) newborns. The basal ganglia (BGT), white matter (WM) and cortex were the three predominant sites of injuries, affecting 33.8% ( = 171), 33.5% ( = 166) and 25.6% ( = 128) of participants, respectively. The thalamus and the periventricular WM were the predominant sublocations. The BGT, posterior limb internal capsule, brainstem and cortical injuries appeared more frequently in the early MRI group than in the late MRI group.
Conclusion: This study described an overview of brain injuries in hypoxic-ischemic neonatal encephalopathy. The basal ganglia with the thalamus and the WM with periventricular sublocation injuries were predominant. Comprehensive identification of brain injuries in the context of HIE may provide insight into the mechanism and time of occurrence.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032533 | PMC |
| http://dx.doi.org/10.3390/children9040561 | DOI Listing |
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