Entropy generation analysis of the flow boiling in microgravity field is conducted in this paper. A new entropy generation model based on the flow pattern and the phase change process is developed in this study. The velocity ranges from 1 m/s to 4 m/s, and the heat flux ranges from 10,000 W/m to 50,000 W/m, so as to investigate their influence on irreversibility during flow boiling in the tunnel. A phase-change model verified by the Stefan problem is employed in this paper to simulate the phase-change process in boiling. The numerical simulations are carried out on ANSYS-FLUENT. The entropy generation produced by the heat transfer, viscous dissipation, turbulent dissipation, and phase change are observed at different working conditions. Moreover, the number and a new evaluation number, , are introduced in this paper to investigate the performance of the boiling phenomenon. The following conclusions are obtained: (1) a high local entropy generation will be obtained when only heat conduction in vapor occurs near the hot wall, whereas a low local entropy generation will be obtained when heat conduction in water or evaporation occurs near the hot wall; (2) the entropy generation and the number are positively correlated with the heat flux, which indicates that the heat transfer entropy generation becomes the major contributor of the total entropy generation with the increase of the heat flux; (3) the transition of the boiling status shows different trends at different velocities, which affects the irreversibility in the tunnel; (4) the critical heat flux (CHF) is the optimal choice under the comprehensive consideration of the first law and the second law of the thermodynamics.
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http://dx.doi.org/10.3390/e24040569 | DOI Listing |
Background: The importance of detecting amyloid β (Aβ) in the early stages of Alzheimer's disease has markedly increased following the approval of Lecanemab, a disease-modifying drug. MRI is a non-invasive and less expensive rather than amyloid PET as gold standard for Aβ biomarker, but its clinical ability to detect Aβ has not been demonstrated. MRI phase information reflects paramagnetic substance including iron associated with Aβ aggregation.
View Article and Find Full Text PDFJ Clin Neurophysiol
January 2025
Department of Intensive Care, Neuro-Intensive Care Unit, University Hospital of Geneva, Geneva, Switzerland.
Purpose: Recent research on quantitative EEG in coma has proposed several metrics correlating with consciousness level. However, the heterogeneous nature of coma can challenge the generalizability of these measures. This study investigates alpha-coma, an electroclinical pattern characterized by a widespread, nonreactive alpha rhythm often linked to poor outcomes.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, USA.
Background: Non-linear statistical analyses on resting-state fMRI (rs-fMRI) using complexity measures have demonstrated progressive decline in complexity from cognitively normal subjects (CN) to patients with Mild Cognitive Impairment (MCI) and patients with Alzheimer's disease (AD). While complexity has been shown to be negatively associated with tau-PET, the association with amyloid or effects of genetic characteristics (APOE4) remains unknown.
Method: From the Alzheimer's Disease Neuroimaging Initiative (ADNI3) we identified participants with tabulated SUVR values for amyloid and tau as well as one resting state fMRI scan for the same visit.
Alzheimers Dement
December 2024
Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Background: Higher cerebrospinal fluid noradrenergic metabolic turnover has been associated with higher levels of Alzheimer's disease pathology in cognitively impaired individuals. It remains unclear whether there is a specific anatomic vulnerability to metabolic alterations within the locus coeruleus (LC) and whether this hypermetabolism relates to steeper rates of pathology accumulation. Here, we overcome a spatial limitation of Positron Emission Tomography (PET) imaging in small nuclei with a dedicated Magnetic Resonance Imaging (MRI)-guided framework to recover PET resolution.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston Salem, NC, USA.
Background: Recent cross-sectional and longitudinal studies have shown that higher activity diversity - defined as richness and evenness of daily activities are beneficial to older adults' cognitive performance. This benefit is independent of frequency or level of cognitive challenge or physical activity.
Method: A total of 1688 participants from the U.
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