AI Article Synopsis

  • PTLD is a serious complication that can occur after organ transplantation, and its risk level varies between kidney and liver transplant recipients.
  • In a study involving nearly 4,000 transplant patients, PTLD was diagnosed more frequently in liver transplant recipients compared to kidney transplant recipients, with different factors influencing the onset and outcomes for each group.
  • Key findings include that older age, male sex, and the use of tacrolimus increase the risk of PTLD, while younger liver transplant recipients had better survival rates and higher chances of complete remission compared to kidney transplant recipients.

Article Abstract

Post-transplantation lymphoproliferative disorder (PTLD) is a life-threatening complication of solid organ transplantation (SOT). Its development risk varies among organ graft recipients. In this study, retrospective data were analyzed to compare PTLD’s risk and prognostic factors between adult kidney and liver transplant recipients (KTRs and LTRs, respectively). Over 15 years, 2598 KTRs and 1378 LTRs were under observation at our center. Sixteen KTRs (0.62%) and twenty-three LTRs (1.67%) were diagnosed with PTLD. PTLD developed earlier in LTRs (p < 0.001), SOT patients > 45 years old (p = 0.002), and patients receiving tacrolimus (p < 0.001) or not receiving cyclosporin (p = 0.03) at diagnosis. Tacrolimus use, male sex, and age > 45 years old significantly affected the time of PTLD onset in KTRs (hazard ratio (HR) = 18.6, 7.9 and 5.2, respectively). Survival was longer in LTRs < 45 years old (p < 0.009). LTRs were more likely than KTRs to achieve complete remission (p = 0.039). Factors affecting PTLD development and outcome differ between KTRs and LTRs; thus, these populations should be separately evaluated in future studies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024969PMC
http://dx.doi.org/10.3390/cancers14081953DOI Listing

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