AI Article Synopsis
- - Head and neck cancer patients often face a higher risk of developing second primary tumors, contributing to a lower survival rate compared to other cancers.
- - The study utilized next-generation sequencing on tumor samples from 13 patients to compare mutations between their first and second oral cancer diagnoses.
- - Results revealed that some patients misdiagnosed as having recurrent cancer actually had primary tumors, emphasizing the potential of genetic testing to improve diagnostic accuracy.
Article Abstract
Head and neck cancer has poor overall survival. Patients with head and neck cancer more frequently develop second primary tumors than do patients with other cancers, leading to a poor prognosis. In this study, we used next-generation sequencing to analyze and compare mutations between first tumors and second tumors in oral cancer. We retrieved tumor tissues collected from 13 patients who were diagnosed twice as having cancer. We used driver gene and trunk mutations to distinguish between recurrent cancer and primary cancer in oral cancer. We observed unique driver gene mutations in three patients with an initial clinical diagnosis of recurrent cancer; hence, we believe that the corresponding patients had primary cancer. Four patients with an initial clinical diagnosis of primary cancer were found to actually have recurrent cancer according to our results. Genetic testing can be used to enhance the accuracy of clinical diagnosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025858 | PMC |
| http://dx.doi.org/10.3390/diagnostics12040951 | DOI Listing |
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