Followed by a buildup of its phytochemical profile, is being subjected to antimicrobial investigation guided with its ethnobotanical use. The results of performed in vitro screening on , , and strains, show that has antimicrobial activity, with a particular emphasis on clinical strains-both the methicillin sensitive (MSSA) and the methicillin resistant (MRSA) . Experimental design consisted of general methods (the serial microdilution broth assay and the agar well diffusion assay), as well as observing bactericidal/bacteriostatic activity through time (the "time-kill" assay), investigating the effect on cell wall integrity and biofilm formation, and modulation of bacterial hemolysis. Observed antibacterial activity from above-described methods led to further activity-guided fractionation of water and methanol extracts using bioautography coupled with UHPLC-LTQ OrbiTrap MS. It was determined that active fractions are predominantly formed by gallic acid derivatives and flavonol glycosides. Among the most active phytochemicals, galloyl-shikimic acid was identified as the most abundant compound. These results point to a direct connection between galloyl-shikimic acid and the observed antibacterial activity, and open several new research approaches for future investigation.
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| http://dx.doi.org/10.3390/antibiotics11040492 | DOI Listing |
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