Sialorrhea, uncontrolled, excessive drooling, accompanies different, mostly neurological disorders from childhood to adulthood. With incobotulinumtoxinA (Xeomin, IncoBoNT/A, Merz Pharmaceuticals GmbH), an approved medication for the treatment of sialorrhea has been available since 2019. Patient selection, possible therapy goals, treatment and the management of specific treatment situations build the focus of this interdisciplinary expert consensus recommendations with the intent to facilitate access to treatment and to contribute to qualified botulinum toxin therapy.
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http://dx.doi.org/10.1055/a-1802-6006 | DOI Listing |
Vet Med Sci
January 2025
Department of Surgery, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey.
Objectives: Vomiting is frequently observed in cats after dexmedetomidine administration. This study aimed to compare the efficacy of different antiemetics in preventing vomiting in cats after dexmedetomidine administration.
Methods: Sixty-four cats were randomly allocated to receive saline solution (0.
Sleep Breath
January 2025
Gülhane School of Medicine, Department of Neurology, University of Health Sciences, Ankara, Türkiye.
Background: Our aim was to determine the effect of obstructive sleep apnea syndrome (OSAS) risk on sialorrhea in patients with Parkinson's disease (PD).
Methods: A total of 75 patients with PD (mean age 66.36 ± 8.
Medicina (Kaunas)
December 2024
Department of Psychiatry, University of Melbourne, Parkville 3052, Australia.
Clozapine is a highly effective antipsychotic used for treating treatment-refractory psychotic and mood disorders. However, clozapine also has a serious risk of side effects leading to mortality, particularly its potentiated risk of leading to pneumonia. This review aims to overview the demographic and health-related risk factors leading to pneumonia to better inform risk assessment for clozapine users and to summarise current theories on the mechanisms for clozapine-associated pneumonia.
View Article and Find Full Text PDFBrain Inj
January 2025
Brain Injury Services, Royal Hospital for Neurodisability, London, UK.
Introduction: Sialorrhea may be a consequence of severe acquired brain injury (ABI). Salivary gland botulinum neurotoxin (SG-BoNT) injections can reduce saliva production, but there is limited evidence for their use in ABI.We reviewed the effectiveness, impact on chest infection frequency, and safety of SG-BoNT for sialorrhea in a cohort of patients with severe ABI.
View Article and Find Full Text PDFJ Clin Psychopharmacol
October 2024
TOBB University of Economics and Technology, Faculty of Medicine, Ankara, Turkey.
Background: Clozapine has demonstrated efficacy in treating treatment-resistant schizophrenia; however, it has a wide range of side effects. Sialorrhea is a common side effect of clozapine that causes the patient to withdraw from social life. This review aims to evaluate and summarize the prevalence, mechanism, risk factors, and management of clozapine-associated sialorrhea.
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