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Divergent response to radio-immunotherapy is defined by intrinsic features of the tumor microenvironment.
J Immunother Cancer
January 2025
Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri, USA
Background: Treatment with immunotherapy can elicit varying responses across cancer types, and the mechanistic underpinnings that contribute to response vrsus progression remain poorly understood. However, to date there are few preclinical models that accurately represent these disparate disease scenarios.
Methods: Using combinatorial radio-immunotherapy consisting of PD-1 blockade, IL2Rβγ biased signaling, and OX40 agonism we were able to generate preclinical tumor models with conflicting responses, where head and neck squamous cell carcinoma (HNSCC) models respond and pancreatic ductal adenocarcinoma (PDAC) progresses.
Heterogeneity of pancreatic neoplasms arising in pancreatic heterotopia: a single institution review.
Virchows Arch
November 2024
Department of Pathology and Immunology, Washington University in St. Louis, 660 South Euclid Avenue, Campus, Box 8118, St. Louis, MO, 63110, USA.
Article Synopsis
- Pancreatic heterotopia (PH) is when pancreatic tissue forms in the gastrointestinal tract and can have various health issues, though cancer development in PH is very uncommon.
- A study reviewed 163 PH cases from 1990 to 2020, finding that 7 had neoplastic processes, including different types of tumors.
- Most affected patients were men around 64 years old, with symptoms such as weight loss and abdominal pain, and it’s critical for pathologists to identify PH to ensure correct diagnosis and staging of potential tumors.
Heterotopic pregnancy and amniotic embolism: a case report.
BMC Pregnancy Childbirth
November 2024
Department of Tocogynecology, Federal University of Paraná, Curitiba, Paraná, Brazil.
Background: Heterotopic pregnancy and amniotic embolism are rare conditions that can be challenging to diagnose. To date, there are no cases of heterotopic pregnancy associated with amniotic embolism described in the literature. Therefore, we report the case of a pancreatic heterotopic pregnancy, which led to amniotic embolism and an unfavorable maternal outcome.
View Article and Find Full Text PDFPancreatic Heterotopia in the Biliary Cyst Wall of a Pregnant Patient and Literature Review.
Int J Surg Pathol
November 2024
Department of General Surgery, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Pancreatic heterotopia is the presence of pancreatic tissue in a different anatomical location with no connection to the main pancreas. The most common locations in the gastrointestinal system are duodenum, stomach, and Meckel diverticulum. However, it is quite rare in the hepatobiliary system.
View Article and Find Full Text PDFAdvances in the diagnosis and treatment of heterotopic pancreas.
World J Clin Cases
October 2024
Department of Hepatobiliary and Pancreatic Surgery, Puer People's Hospital, Puer 665000, Yunnan Province, China.
Article Synopsis
- *Most patients are asymptomatic, and the condition is usually found incidentally during other medical procedures; diagnostic methods include endoscopic ultrasound, CT scans, and MRIs, though these aren't always reliable.
- *Treatment often consists of endoscopic or surgical removal, or simply monitoring the condition over time.*
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