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Guyton's hemodynamic mosaic: crafting fluid management with precision.
Ann Intensive Care
January 2025
Intensive Care Department, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627/701 - Morumbi, São Paulo, CEP: 05651-901, SP, Brasil.
Sheldon Magder's article on applying Arthur Guyton's principles to clinical fluid management provides valuable insights into optimizing hemodynamics in critically ill patients. While emphasizing the role of right atrial pressure (RAP) in assessing cardiac output, challenges arise due to RAP's variable accuracy and the oversimplification of cardiovascular dynamics. Integrating RAP with dynamic assessments and bedside ultrasound can enhance fluid management strategies.
View Article and Find Full Text PDFSuperconductivity from Domain Wall Fluctuations in Sliding Ferroelectrics.
Phys Rev Lett
December 2024
Materials Science Division, Argonne National Laboratory, Lemont, Illinois 60439, USA.
Bilayers of two-dimensional van der Waals materials that lack an inversion center can show a novel form of ferroelectricity, where certain stacking arrangements of the two layers lead to an interlayer polarization. Under an external out-of-plane electric field, a relative sliding between the two layers can occur, accompanied by an interlayer charge transfer and a ferroelectric switching. We show that the domain walls that mediate ferroelectric switching are a locus of strong attractive interactions between electrons.
View Article and Find Full Text PDFReply to: Treat-and-repair: a simple but powerful term for a complex multimodal approach in patients with pulmonary arterial hypertension associated with congenital heart disease.
Eur Respir J
January 2025
Center for Congenital Heart Diseases, Paediatric and Congenital Cardiology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Targeting hypoxia and angiogenesis in hepatocellular carcinoma: New insights and therapeutic strategies.
World J Hepatol
December 2024
Department of Infectious Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
In this manuscript we comment on the article by Yang published recently, focusing on how hepatic angiopoietin-2 (Ang-2) transcription promote the progression of hepatocellular carcinoma (HCC). HCC is one of the most common and lethal malignancies worldwide, especially in regions with high hepatitis B virus infection rates. Ang-2 is a key mediator of angiogenesis and plays a significant role in the progression of chronic liver diseases towards HCC, particularly in the hypoxic microenvironment.
View Article and Find Full Text PDFTouching at a distance: the elaboration of communicative functions from the perspective of the interactants.
Front Psychol
December 2024
i3, UMR-9217 CNRS Télécom Paris, Institut Polytechnique de Paris, Palaiseau, France.
Touch is an inherent part of human social interactions and the diversity of its functions has been highlighted in numerous works. Given the varied roles of touch, with technology-mediated communication being a big part of our everyday lives, research has been interested in enabling and enhancing distant social interactions with mediated touch over networks. Due to the complexity of the sense of touch and technological limitations, multimodal devices have been developed and investigated.
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