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Real-World Pitfalls of Analyzing Real-World Data: A Cautionary Note and Path Forward.
JCO Clin Cancer Inform
September 2023
Walter Reed National Military Medical Center, Bethesda, MD.
Purpose: Real-world data (RWD) are pervasive in oncology research and offer insights into clinical trends and patient outcomes. However, RWD have shortcomings, making them prone to pitfalls during survival analyses. The American Society of Clinical Oncology (ASCO) CancerLinQ Discovery (CLQD) multiple myeloma (MM) data set was used to demonstrate some common pitfalls when analyzing survival from RWD: using incorrect surrogate markers for missing data and/or classification errors, ignoring deaths at time zero, and failing to account for guarantee-time bias.
View Article and Find Full Text PDFRespective Roles of Surgery, Chemotherapy, and Radiation Therapy for Recurrent Pediatric and Adolescent Ependymoma: A National Multicentric Study.
Int J Radiat Oncol Biol Phys
October 2023
Department of Radiation Oncology, Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France; Université Toulouse III Paul Sabatier, Toulouse, France; Toulouse NeuroImaging Center, ToNIC, Université de Toulouse, Inserm, UPS, Toulouse, France. Electronic address:
Purpose: Half of the children and adolescents treated for intracranial ependymoma experience recurrences that are not managed in a standardized manner. This study aimed to retrospectively evaluate recurrence treatments.
Methods And Materials: We assessed overall survival (OS) and progression-free survival (PFS) after a first relapse in a population of patients from the Pediatric Ependymoma Photons Protons and Imaging study (PEPPI study) who were treated with surgery and radiation therapy in French Society of Childhood Cancer reference centers between 2000 and 2013.
Patient benefit rate and guarantee time bias in analysis of outcomes for gynecologic oncology patients receiving targeted treatment after somatic tumor genetic testing.
Gynecol Oncol Rep
August 2022
Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA.
Guarantee-time bias in studies on the relationship between immune-related adverse events and antitumor activity.
Cancer
July 2022
Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong SAR.
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