"De novo" genes evolve from previously non-genic DNA. This strikes many of us as remarkable, because it seems extraordinarily unlikely that random sequence would produce a functional gene. How is this possible? In this two-part review, I first summarize what is known about the origins and molecular functions of the small number of de novo genes for which such information is available. I then speculate on what these examples may tell us about how de novo genes manage to emerge despite what seem like enormous opposing odds.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233646 | PMC |
| http://dx.doi.org/10.1007/s00239-022-10055-3 | DOI Listing |
Publication Analysis
Top Keywords
novo genes
12
origins functions
4
functions novo
4
genes
4
genes odds?
4
odds? "de
4
"de novo"
4
novo" genes
4
genes evolve
4
evolve non-genic
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!