AI Article Synopsis
- - A new hydrogel made from chitosan oligosaccharide and alginate was created using a special chemical reaction to help deliver the drug ketoprofen, demonstrating its ability to hold a significant amount of the drug (44% by weight).
- - The hydrogel features a pH-responsive design that keeps drug release low in acidic conditions (like gastric fluid) but increases it in less acidic environments (like intestinal fluid), with release rates of over 84% in 24 hours.
- - Testing showed that the hydrogel is safe for human cells, indicating its potential for using natural materials to create effective drug delivery systems for hydrophobic medications.
Article Abstract
A novel physically and chemically double-crosslinked hydrogel derived from chitosan oligosaccharide/alginate (COS/Alg) was developed by using norbornene (Nb)-tetrazine (Tz) click reaction for ketoprofen delivery. The properties of the hydrogel were evaluated by rheological, FTIR, TGA, XRD, SEM, swelling and drug release studies. The Nb-Tz chemical cross-linking facilitated outstanding hydrophobic drug loading (44% wt/wt of ketoprofen) and sustained release through a hydrophobic interaction mechanism between the drug and the used polysaccharides. The COS/Alg electrostatics network (10/10 of NH/COOH molar ratio) generated the pH responsiveness, suppressing the release in simulated gastric fluid (below 10% for 2 h) and enhancing the release in simulated intestinal fluids (up to 84% for 24 h). The prepared hydrogel was non-toxic to human HEK-293 cells (95% cell viability). This work opens up a potential approach for preparing hydrophilic hydrogels from natural polysaccharides that can be used in the delivery of hydrophobic drugs.
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| http://dx.doi.org/10.1016/j.carbpol.2022.119389 | DOI Listing |
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