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The potential therapeutic role of berberine in treating epilepsy focusing on temporal lobe epilepsy: State of art and ongoing perspective.
Brain Res Bull
January 2025
Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, 22511, AlBeheira, Egypt. Electronic address:
Epilepsy is a neurological disease characterized by unprovoked recurrent epileptic seizures. Temporal lobe epilepsy (TLE) is the commonest type of focal epilepsy in adults that resist to the conventional anti-seizure medications (ASMs). Interestingly, ASMs do not affect the epileptogenesis and progression of disease.
View Article and Find Full Text PDFPPI-CoAttNet: A Web Server for Protein-Protein Interaction Tasks Using a Coattention Model.
J Chem Inf Model
January 2025
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Predicting protein-protein interactions (PPIs) is crucial for advancing drug discovery. Despite the proposal of numerous advanced computational methods, these approaches often suffer from poor usability for biologists and lack generalization. In this study, we designed a deep learning model based on a coattention mechanism that was capable of both PPI and site prediction and used this model as the foundation for PPI-CoAttNet, a user-friendly, multifunctional web server for PPI prediction.
View Article and Find Full Text PDFStabilization of small organic molecules on VC and VCO MXenes: first-principles insights into the performance of van der Waals functionals and the effect of oxygen vacancies.
RSC Adv
January 2025
New Industry Creation Hatchery Center, Tohoku University Sendai 980-8579 Japan.
The adsorption of small organic molecules on pristine VC MXene and its derivatives is investigated by first-principles density functional theory calculations. By employing state-of-the-art van der Waals (vdW) density functionals, the binding affinity of studied molecules, , CH, CO, and HO on MXene adsorbents is well described by more recent vdW functionals, , SCAN-rvv10. Although both CH and CO are nonpolar molecules, on pristine and oxygen-vacancy surfaces, they show a different range of adsorption energies, in which CH is more inert and has weaker binding than CO.
View Article and Find Full Text PDFPrecision Oncology: Advances in Drug Delivery and Imaging.
Recent Adv Drug Deliv Formul
December 2024
Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Pharmaceutics, Gujarat, India.
The development of precise and reliable cancer treatments has been a long-standing goal in oncology. Conventional therapies often affect healthy tissues, leading to significant side effects. To overcome these challenges, researchers are exploring new methodologies that combine advanced drug delivery systems with state-of-the-art imaging technologies to target tumors more effectively.
View Article and Find Full Text PDFMeasuring the uptake of clinic-based HIV treatment and prevention services following HIV testing and referral at private pharmacies in Kenya.
BMC Health Serv Res
January 2025
Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, USA.
Background: Despite their ubiquity across sub-Saharan Africa, private pharmacies are underutilized for HIV service delivery beyond the sale of HIV self-test kits. To understand what uptake of HIV prevention and treatment services might look like if private pharmacies offered clients free HIV self-testing and referral to clinic-based HIV services, we conducted a pilot study in Kenya.
Methods: At 20 private pharmacies in Kisumu County, Kenya, pharmacy clients (≥ 18 years) purchasing sexual health-related products (e.
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