A tale of two intensive care units (ICUs): Baseline colonization and mupirocin susceptibility in neonatal and pediatric patients requiring intensive care.

Objective: To assess the incidence rate of colonization at baseline along with the mupirocin susceptibility (or resistance) rate in patients in a neonatal intensive care unit (NICU) and a pediatric intensive care unit (PICU) in conjunction with the implementation of universal decolonization as the standard of care.

Design: Prospective cohort study.

Setting: Children's Hospital of Michigan (CHM) inpatient intensive care units (ICUs).

Participants: Newly admitted pediatric patients to the CHM NICU or PICU aged between 1 day and ≤21 years.

Interventions: Baseline and follow-up screening cultures were obtained before patients underwent universal decolonization with mupirocin 2% antibiotic ointment (intranasal and umbilical) and chlorhexidine baths as standard of care to reduce CLABSI rates.

Results: Baseline colonization rates of new admissions to the CHM NICU and PICU were high at 32% and 29%, respectively. Baseline mupirocin susceptibility to any growth was 98.4%. All baseline culture isolates whether positive for MRSA or MSSA, with one exception, had minimum inhibitory concentrations (MICs) of ≤0.19 µg/mL. All follow-up study cultures after universal decolonization at 7 days or beyond with any growth had mupirocin MICs of ≤0.125 µg/mL.

Conclusions: Baseline colonization rates of new admissions to the CHM ICUs were high as was baseline mupirocin susceptibility. Follow-up cultures, albeit limited in number, did not detect increasing mupirocin MICs over 1 year, despite broad mupirocin exposure due to the implementation of universal decolonization.