Chromosome and array comparative genomic hybridization (aCGH) analyses were performed on two cases of well-differentiated liposarcoma (WDLPS) and two cases of dedifferentiated liposarcoma (DDLPS). The results revealed the characteristic giant ring (GR) or giant rod marker (GRM) chromosomes in all four cases and amplification of numerous somatic copy number alterations (SCNAs) involving a core segment of 12q14.1q15 and other chromosomal regions in three cases. The levels of amplification for oncogenes OS9, CDK4, HMGA2, NUP107, MDM2, YEATS4, and FRS2 at the core segment or other SCNAs should be characterized to facilitate pathologic correlation and prognostic prediction. Further studies for the initial cellular crisis event affecting chromosome intermingling regions for cell-type specific gene regulation may reveal the underlying mutagenesis mechanism for GR and GRM in WDLPS and DDLPS.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018199 | PMC |
| http://dx.doi.org/10.1155/2022/6341207 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Grade 4 astrocytoma vs. grade 4 glioblastoma: is there any clue in H&E?
Int J Neurosci
December 2024
Department of Pathology, Ankara University Medical School, Ankara, Turkey.
Gliomas are the most common primary tumors of the central nervous system. The fifth edition of the World Health Organization (WHO) Classification of Tumors of the CNS identifies IDH mutant astrocytomas grade 4 and IDH wild type glioblastomas grade 4 as distinct entities. This study aimed to identify morphological indicators that could predict IDH mutation status in grade 4 diffuse astrocytomas and grade 4 glioblastomas among fifty patients from two groups.
View Article and Find Full Text PDFGiant primary omental cyst: an unusual cause of pseudoascites and hydrocele in a child.
J Surg Case Rep
December 2024
Department of Pediatric Surgery, Hamad Medical Cooperation, Doha 2001, Qatar.
Abdominal lymphangiomas are benign congenital abnormal dilatation and proliferation of lymphatic spaces primarily seen in children. The wide spectrum of symptoms challenges preoperative diagnoses. We present a rare case of a 2-year-old boy presented to pediatrician with massive abdominal distention and left scrotal swelling since the age of 1½ years.
View Article and Find Full Text PDFGiant right coronary artery aneurysm presenting with recurrent syncope: A diagnostic challenge.
Radiol Case Rep
February 2025
Faculty of medicine, Mogadishu University, Mogadishu, Somalia.
Coronary artery aneurysm (CAA) is a rare form of coronary artery disease characterized by abnormal dilation of a coronary artery segment. While CAAs can present with various symptoms, syncope is notably uncommon, with limited documented cases. We present the case of a 24-year-old woman with a 2-month history of recurrent syncope, occurring in the absence of other symptoms.
View Article and Find Full Text PDFGiant cerebellar neurocysticercosis masquerading a primary central nervous system neoplasm - A case report with review of literature.
Surg Neurol Int
November 2024
Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Background: Neurocysticercosis (NCC) is one of the leading parasitic infections of the brain. Giant NCC is rare, with only two cases of cerebellar involvement reported till now. In the presence of a host immune response, these giant NCCs can mimic primary central nervous system neoplasms.
View Article and Find Full Text PDFEnergetic neutral atom imaging reveals nearly 11-year cycle of the ring current of Saturn.
Nat Commun
December 2024
Institute of Space Physics and Applied Technology, Peking University, Beijing, China.
The drift motion of energetic charged particles can generate an azimuthal electric current around the planet known as the ring current, which regulates the field configuration of the magnetosphere. However, limited coverage of in-situ measurements makes it challenging to investigate the long-term variations of the global ring current. Taking advantage of the energetic neutral atom (ENA) imaging onboard the Cassini mission, we present a nearly 11-year cycle of the suprathermal ring current populations in Saturn's magnetosphere.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!