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Detection of Serotonin, Melatonin, and Their Metabolites in Honey. | LitMetric

Detection of Serotonin, Melatonin, and Their Metabolites in Honey.

ACS Food Sci Technol

Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States; VA Medical Center, Birmingham, Alabama 35294, United States.

Published: August 2021

AI Article Synopsis

  • Melatonin and serotonin, which are neurotransmitters and hormones derived from tryptophan, were identified and measured in natural honey from Australia, the USA, and Poland using a specific mass spectrometry technique.
  • The concentration of these metabolites varied based on the honey's origin, with Australian honey showing specific levels of melatonin and its derivative.
  • The study suggests that the presence of serotonin, melatonin, and their metabolites in honey could be linked to its health benefits and might also influence bee colony behavior.

Article Abstract

Melatonin and serotonin, products of tryptophan metabolism, are endogenous neurotransmitters and hormones. We have identified and quantified these metabolites in natural honey from Australia, USA, and Poland using a Xevo G2 XS qTof LC-MS. To help ensure correct product identification, some samples were prepurified by RP-HPLC based on the retention times of standards, prior to LC-MS. The concentrations of the metabolites of interest depended on the source of the honey. For Australian honey, levels for melatonin and 2-hydroxymelatonin were 0.91 and 0.68 ng/g, respectively. Melatonin was detected in one brand of US commercial honey at 0.48 ng/g, while a second brand contained serotonin at 88.2 ng/g. In Polish natural honey, 20.6 ng/g of serotonin and 40.8 ng/g of -acetylserotonin (NAS) were detected, while in Polish commercial honey 25.9 ng/g of serotonin and 7.30 ng/g of NAS were present. We suggest that addictive and health-related properties of honey may be in part dependent on the presence of serotonin, melatonin, and their metabolites, and that these compounds may play a role in the colony activities of bees.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017714PMC
http://dx.doi.org/10.1021/acsfoodscitech.1c00119DOI Listing

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