AI Article Synopsis
- * A case study involved a 42-year-old woman who developed heart muscle disease (non-ischemic cardiomyopathy) after taking ibrutinib for four months, despite not having heart rhythm issues.
- * After stopping the medication, her heart function improved quickly, suggesting that the cardiomyopathy may be reversible and highlighting the need for doctors to monitor heart health in patients taking ibrutinib.
Article Abstract
Ibrutinib is an irreversible Bruton tyrosine kinase inhibitor that is approved for the treatment of mantle cell lymphoma, chronic lymphocytic leukemia, small lymphocytic lymphoma, Waldenström macroglobulinemia, marginal zone lymphoma, and mantle cell lymphoma. However, it is associated with significant cardiotoxic effects, with hypertension and atrial fibrillation being the most common. We present the case of a 42-year-old female with a medical history significant for lymphoplasmacytic lymphoma who presented with non-arrhythmic, non-ischemic cardiomyopathy after four months of chemotherapy with ibrutinib. In addition, her left ventricular ejection fraction improved markedly within a few days of stopping ibrutinib. We propose that the use of ibrutinib may be associated with reversible non-ischemic cardiomyopathy even in the absence of cardiac arrhythmias. Therefore, clinicians should be cognizant of the signs and symptoms of cardiomyopathy in patients on ibrutinib chemotherapy.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9013282 | PMC |
| http://dx.doi.org/10.7759/cureus.23266 | DOI Listing |
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