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Leveraging human microbiomes for disease prediction and treatment.
Trends Pharmacol Sci
December 2024
Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA; Texas Children's Microbiome Center, Department of Pathology, Texas Children's Hospital, Houston, TX, USA. Electronic address:
The human microbiome consists of diverse microorganisms that inhabit various body sites. As these microbes are increasingly recognized as key determinants of health, there is significant interest in leveraging individual microbiome profiles for early disease detection, prevention, and drug efficacy prediction. However, the complexity of microbiome data, coupled with conflicting study outcomes, has hindered its integration into clinical practice.
View Article and Find Full Text PDFMowing facilitated Pb accumulation in bermudagrass by mediating root radial transport.
Plant Physiol Biochem
December 2024
College of Landscape Architecture, Sichuan Agricultural University, Chengdu, Sichuan, 611130, China. Electronic address:
Moderate mowing of the shoot is an effective strategy for improving Pb-contaminated soil remediation using bermudagrass. However, the mechanisms by which mowing facilitates Pb uptake and accumulation remain insufficiently understood. Root radial transport is critical in efficient heavy metal uptake and translocation in plants and is influenced by root physiological-biochemical characteristics.
View Article and Find Full Text PDFPractical surgical tips on performing upper blepharoplasty.
World J Clin Cases
December 2024
Department of Ophthalmology, Tung Wah Eastern Hospital, Hong Kong 999077, China.
Upper lid blepharoplasty is a surgical procedure that requires meticulous planning and execution. It is not a standalone procedure but can be combined with ptosis correction surgery. Prior to surgery, thorough lid examinations are essential to determine the appropriate approaches.
View Article and Find Full Text PDFRepair of Acute Grade-3 Combined Posterolateral Corner Avulsion Injuries Using a Transosseous Krackow Suture Pull-Through Technique.
JBJS Essent Surg Tech
December 2024
Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, Connecticut.
Background: For complete disruption of the posterolateral corner (PLC) structures, operative treatment is most commonly advocated, as nonoperative treatment has higher rates of persistent lateral laxity and posttraumatic arthritis. Some studies have shown that acute direct repair results in revision rates upwards of 37% to 40% compared with 6% to 9% for initial reconstruction. In a recent study assessing the outcomes of acute repair of PLC avulsion injuries with 2 to 7 years of follow-up, patients with adequate tissue were shown to have a much lower failure rate than previously documented.
View Article and Find Full Text PDFProtocol of an adaptive mobile health intervention for the management of gestational weight gain: The LEAP cluster randomized controlled trial.
Contemp Clin Trials
December 2024
Kaiser Permanente Northern California, Division of Research, Pleasanton, CA, United States of America; UPSTREAM - Center for Upstream Prevention of Adiposity and Diabetes Mellitus; Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, United States of America.
Background: More than half of pregnant patients with overweight or obesity exceed national gestational weight gain (GWG) guidelines, increasing their risk of adverse outcomes. There is an urgent need to develop effective and scalable interventions to improve GWG.
Objective: To describe the protocol of Lifestyle, Eating, and Activity in Pregnancy (LEAP), a cluster randomized controlled trial evaluating a mobile health (mHealth) intervention promoting appropriate GWG in an integrated healthcare system.
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