AI Article Synopsis

  • p-Cresyl sulfate (PCS) is a harmful substance that contributes to heart issues in chronic kidney disease (CKD) patients, particularly affecting vascular health.
  • Researchers examined the link between serum PCS levels and peripheral arterial stiffness (PAS) using data from 160 CKD patients, finding 33.8% had elevated PAS.
  • The study concluded that higher PCS levels are significantly associated with increased risks of PAS, alongside factors like older age and blood pressure, highlighting the importance of monitoring PCS in CKD treatment.

Article Abstract

p-Cresyl sulfate (PCS) is a uremic toxin that causes cardiovascular injury and progression in patients with chronic kidney disease (CKD). Peripheral arterial stiffness (PAS) as measured using the brachial-ankle pulse wave velocity (baPWV) is considered a valuable predictor of cardiovascular event risk in the general population. The study investigated the correlation between serum PCS levels and PAS (baPWV > 18.0 m/s) in 160 patients with stage 3−5 CKD. Liquid chromatography−mass spectrometry was used to assay serum PCS levels. PAS was detected in 54 patients (33.8%), and it was linked to older age, a higher prevalence of hypertension, higher systolic and diastolic blood pressure, higher serum calcium−phosphorus product and PCS levels, and lower height and body weight. Multivariable logistic regression analysis for independent factors associated with PAS illustrated that, in addition to age and diastolic blood pressure, serum PCS levels exhibited an odds ratio (OR) of 1.098 (95% confidence interval = 1.029−1.171, p = 0.005). These findings demonstrated that serum PCS levels were associated with PAS among patients with stage 3−5 CKD.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032097PMC
http://dx.doi.org/10.3390/toxins14040287DOI Listing

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