AI Article Synopsis
- Researchers developed an antivenom (HcuAV) derived from horse plasma immunized with sea snake venom, which showed strong effectiveness in lab tests.
- HcuAV significantly improved survival rates in mice bitten by sea snakes and helped reduce organ damage, indicating its potential for future clinical use.
Article Abstract
Sea snake venom is extremely toxic, and it can induce severe respiratory failure and cause high mortality. The most effective first aid treatment for sea snake bites is to inject antivenom as soon as possible. However, in China, there are only four types of terrestrial snake antivenoms, none of which are effective in the treatment of sea snake bites. In order to develop an antivenom for the dominant species of sea snakes in Chinese seas, venom (HcuV) was chosen as the antigen to immunize horses. From immune plasma, a high-titer antivenom (HcuAV) was prepared. In vitro assessment showed that HcuAV had a cross-neutralizing capacity against HcuV and venom (HcyV). In vivo assessment indicated that HcuAV injection could significantly improve the survival rates of the HcuV and HcyV envenomated mice (0% to 100% and 87.5%, respectively) when it was injected at a sufficient amount within the shortest possible time. In addition, HcuAV could also effectively alleviate multiple organ injuries caused by HcuV. These results provide experimental support for the future clinical application of HcuAV.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9024827 | PMC |
| http://dx.doi.org/10.3390/toxins14040253 | DOI Listing |
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