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Bcl-2 Immunoexpression in Feline Epitheliotropic Intestinal T-Cell Lymphomas. | LitMetric

AI Article Synopsis

  • Lymphoma is identified as the most common type of cancer affecting the blood system in cats, particularly involving duodenal T-cells in domestic felines.
  • A study of 22 cases revealed that the majority were domestic shorthair cats averaging 11.2 years old, with all lymphomas expressing specific markers like CD3 and Bcl-2, indicating varying degrees of tumor progression.
  • Findings suggested a significant correlation between tumor characteristics and the presence of Bcl-2, which could serve as a predictor for disease severity and progression in feline intestinal T-cell lymphomas, showing parallels with human medical cases.

Article Abstract

Lymphoma is the most common malignant hematopoietic neoplasm in domestic felines. Twenty-two cases of feline epitheliotropic duodenal T-cell lymphoma were characterized morphologically and immunohistochemically (CD3, Pax5, Ki-67), and Bcl-2 immunoexpression was established. Most cases were in domestic shorthair cats (88.2%), with a mean age of 11.2 years. All lymphomas were CD3+, with a low-to-moderate expression of Ki-67 (<30%). A correlation between the tumoral pattern of infiltration in the lamina propria and the intraepithelial distribution of the neoplastic lymphocytes was established (p = 0.0155). Intraepithelial nests of neoplastic lymphocytes were predominantly observed in lymphomas with a patchy distribution in the lamina propria, whereas intraepithelial plaques were seen in lymphomas with an obliteration pattern. Bcl-2 was expressed in neoplastic cells in all cases, and a higher expression was associated with increased villous stunting (p = 0.0221), and tended to be present in those cases with increased epithelial damage. The expression of Bcl-2 and the degree of epitheliotropism were correlated with neoplastic progression in epitheliotropic intestinal T-cell lymphomas; those displaying high Bcl-2 immunoexpression showed increased villous stunting and epithelial damage, suggesting that Bcl-2 is overexpressed in advanced tumor stages, and may be used as a predictor of tumoral behavior in feline epitheliotropic intestinal T-cell lymphomas. This entity showed many similarities with human MEITL, so the latter entity should be considered in further lymphoma classifications of domestic animals.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9028225PMC
http://dx.doi.org/10.3390/vetsci9040168DOI Listing

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