Explainable Multimedia Feature Fusion for Medical Applications.

J Imaging

Faculty of Mathematics and Computer Science, University of Hagen, Universitätsstrasse 1, 58097 Hagen, Germany.

Published: April 2022

Due to the exponential growth of medical information in the form of, e.g., text, images, Electrocardiograms (ECGs), X-rays, and multimedia, the management of a patient's data has become a huge challenge. In particular, the extraction of features from various different formats and their representation in a homogeneous way are areas of interest in medical applications. Multimedia Information Retrieval (MMIR) frameworks, like the Generic Multimedia Analysis Framework (GMAF), can contribute to solving this problem, when adapted to special requirements and modalities of medical applications. In this paper, we demonstrate how typical multimedia processing techniques can be extended and adapted to medical applications and how these applications benefit from employing a Multimedia Feature Graph (MMFG) and specialized, efficient indexing structures in the form of Graph Codes. These Graph Codes are transformed to feature relevant Graph Codes by employing a modified Term Frequency Inverse Document Frequency (TFIDF) algorithm, which further supports value ranges and Boolean operations required in the medical context. On this basis, various metrics for the calculation of similarity, recommendations, and automated inferencing and reasoning can be applied supporting the field of diagnostics. Finally, the presentation of these new facilities in the form of explainability is introduced and demonstrated. Thus, in this paper, we show how Graph Codes contribute new querying options for diagnosis and how Explainable Graph Codes can help to readily understand medical multimedia formats.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032787PMC
http://dx.doi.org/10.3390/jimaging8040104DOI Listing

Publication Analysis

Top Keywords

graph codes
20
medical applications
16
multimedia feature
8
medical
7
multimedia
6
graph
6
applications
5
codes
5
explainable multimedia
4
feature fusion
4

Similar Publications

On topological characterizations and computational analysis of benzenoid networks for drug discovery and development.

J Mol Graph Model

January 2025

Department of Mathematics & Actuarial Science, B. S. Abdur Rahman Crescent Institute of Science and Technology, Chennai, Tamil Nadu, 600048, India. Electronic address:

Topological indices are numerical invariants that provide key insights into the structural properties of molecular graphs and are crucial in predicting physio-chemical and biological activities. This paper applies established computational methodologies for analyzing benzenoid networks and their application to polycyclic aromatic hydrocarbons (PAHs) through degree-based topological indices computed via M-polynomial and NM-polynomial approaches. By examining tessellations, including linear chain, hexagonal, rhomboidal, and triangular configurations alongside their line graphs, this work highlights the influence of molecular topology on biological activity.

View Article and Find Full Text PDF

TFinder: A Python Web Tool for Predicting Transcription Factor Binding Sites.

J Mol Biol

February 2025

University Côte d'Azur, INSERM, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, "Laboratory of Excellence (LABEX) Distalz", Valbonne, France. Electronic address:

Transcription is a key cell process that consists of synthesizing several copies of RNA from a gene DNA sequence. This process is highly regulated and closely linked to the ability of transcription factors to bind specifically to DNA. TFinder is an easy-to-use Python web portal allowing the identification of Individual Motifs (IM) such as Transcription Factor Binding Sites (TFBS).

View Article and Find Full Text PDF

Motivation: The drug-disease, gene-disease, and drug-gene relationships, as high-frequency edge types, describe complex biological processes within the biomedical knowledge graph. The structural patterns formed by these three edges are the graph motifs of (disease, drug, gene) triplets. Among them, the triangle is a steady and important motif structure in the network, and other various motifs different from the triangle also indicate rich semantic relationships.

View Article and Find Full Text PDF

Graph Neural Networks-Based Prediction of Drug Gene Interactions of RTK-VEGF4 Receptor Family in Periodontal Regeneration.

J Clin Exp Dent

December 2024

DDS. Titular Professor. Universidad de Antioquia U de A, Medellín, Colombia. Biomedical Stomatology Research Group, Universidad de Antioquia U de A, Medellín, Colombia.

Background: The RTK-VEGF4 receptor family, which includes VEGFR-1, VEGFR-2, and VEGFR-3, plays a crucial role in tissue regeneration by promoting angiogenesis, the formation of new blood vessels, and recruiting stem cells and immune cells. Machine learning, particularly graph neural networks (GNNs), has shown high accuracy in predicting these interactions. This study aims to predict drug-gene interactions of the RTK-VEGF4 receptor family in periodontal regeneration using graph neural networks.

View Article and Find Full Text PDF

MultiChem: predicting chemical properties using multi-view graph attention network.

BioData Min

January 2025

Department of Computer Science, Hanyang University, Seoul, Republic of Korea.

Background: Understanding the molecular properties of chemical compounds is essential for identifying potential candidates or ensuring safety in drug discovery. However, exploring the vast chemical space is time-consuming and costly, necessitating the development of time-efficient and cost-effective computational methods. Recent advances in deep learning approaches have offered deeper insights into molecular structures.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!