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Passage of the HIV capsid cracks the nuclear pore.
Cell
January 2025
Department of Molecular Sociology, Max Planck Institute of Biophysics, Max-von-Laue-Straße 3, 60438 Frankfurt am Main, Germany; Institute of Biochemistry, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany. Electronic address:
Upon infection, human immunodeficiency virus type 1 (HIV-1) releases its cone-shaped capsid into the cytoplasm of infected T cells and macrophages. The capsid enters the nuclear pore complex (NPC), driven by interactions with numerous phenylalanine-glycine (FG)-repeat nucleoporins (FG-Nups). Whether NPCs structurally adapt to capsid passage and whether capsids are modified during passage remains unknown, however.
View Article and Find Full Text PDFSuper-Resolution Goes Viral: T4 Virus Particles as Versatile 3D-Bio-NanoRulers.
Adv Mater
January 2025
Third Institute of Physics - Biophysics, Georg August University, Friedrich-Hund Platz 1, 37077, Göttingen, Germany.
In the burgeoning field of super-resolution fluorescence microscopy, significant efforts are being dedicated to expanding its applications into the 3D domain. Various methodologies have been developed that enable isotropic resolution at the nanometer scale, facilitating the visualization of 3D subcellular structures with unprecedented clarity. Central to this progress is the need for reliable 3D structures that are biologically compatible for validating resolution capabilities.
View Article and Find Full Text PDFDo cytokines play a role in the transition from acute to chronic musculoskeletal pain?
Pharmacol Res
January 2025
University Hospital of Jena, Institute of Physiology 1, Jena D-07740, Germany. Electronic address:
Musculoskeletal pain has a high prevalence of transition to chronic pain and/or persistence as chronic pain for years or even a lifetime. Possible mechanisms for the development of such pain states are often reflected in inflammatory or neuropathic processes involving, among others, cytokines and other molecules. Since biologics such as blockers of TNF or IL-6 can attenuate inflammation and pain in a subset of patients with rheumatoid arthritis, the question arises to what extent cytokines are involved in the generation of pain in human musculoskeletal diseases.
View Article and Find Full Text PDFMRI classification of progressive supranuclear palsy, Parkinson disease and controls using deep learning and machine learning algorithms for the identification of regions and tracts of interest as potential biomarkers.
Comput Biol Med
February 2025
Department of Neurology, University of Ulm, Ulm, Germany. Electronic address:
Background: Quantitative magnetic resonance imaging (MRI) analysis has shown promise in differentiating neurodegenerative Parkinsonian syndromes and has significantly advanced our understanding of diseases like progressive supranuclear palsy (PSP) in recent years.
Objective: The aim of this study was to develop, implement and compare MRI analysis algorithms based on artificial intelligence (AI) that can differentiate PSP not only from healthy controls but also from Parkinson disease (PD), by analyzing changes in brain structure and microstructure. Specifically, this study focused on identifying regions of interest (ROIs) and tracts of interest (TOIs) that are crucial for the algorithms to provide clinically relevant performance indices for the distinction between disease variants.
Emission patterns of volatile organic compounds from Norway spruce logs following bark beetle (Ips typographus L.) infestation.
Tree Physiol
December 2024
Chair of Ecosystem Physiology, University of Freiburg, Georges-Köhler-Allee 53, Freiburg 79110, Germany.
Norway spruce (Picea abies L.) is economically one of the most important conifer species in Europe. Spruce forests are threatened by outbreaks of the bark beetle Ips typographus L.
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