AI Article Synopsis
- Vγ6 γδ T cells, which primarily produce IL-17A, develop in the thymus during the perinatal stage.
- A lack of MHC class II results in an increased number of IL-17A producing Vγ6 γδ T cells in the thymus.
- This suggests that MHC class II plays a role in limiting the production of IL-17A Vγ6 γδ T cells during their development.
Article Abstract
Vγ6 γδ T cells develop in the thymus at the perinatal stage and are exclusive IL-17A producers among γδ T cells. The loss of MHC class II led to the expansion of IL-17A Vγ6 γδ T cells in the thymus. Thus, MHC class II in the thymus inhibits the generation of IL-17A Vγ6 γδ T cells.
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| http://dx.doi.org/10.1002/eji.202149542 | DOI Listing |
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