The dysfunctional islet β-cell triggered by excessive deposition of Zn constituted a striking indicator of the occurrence of diabetic disease. However, it remained a formidable challenge to reflect the real-time function of β-cell by monitoring the Zn content. Herein, multistage photoactivatable Zn-responsive nanodevice (denoted as AD2@USD1) was presented for sensing, regulating, and evaluating Zn levels in dysfunctional islet β-cells. The photoactivated signatures on the satellite shell layer of the nanodevices and the internally loaded chelating factors effectively identified and intervened in the real-time concentration of Zn, the photothermal feedback component decorated on the inner core permitted the assessment of the post-intervention Zn levels, achieving an integrated intervention and prognostic assessment in response to the abnormal islet β-cell function induced by Zn deposition. In this way, one strategy for sensing and regulating islet β-cell function-oriented to Zn was established. Our study introduced AD2@USD1 as a tool for effectively sensing, adjusting, and assessing the Zn level in islet β-cells with abnormalities, gaining a potential breakthrough in the treatment of diabetes.
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http://dx.doi.org/10.1021/acs.analchem.2c00892 | DOI Listing |
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